| ZFIN ID: ZDB-EXP-240227-11 |
Experiment Conditions Description: chemical treatment by environment: rofecoxib
| chemical treatment by environment: rofecoxib |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | rofecoxib |
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| Synonyms: | 3-phenyl-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone, 4-[4-(methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone, 4-[4-(methylsulfonyl)phenyl]-3-phenylfuran-2(5H)-one, Ceoxx, rofecoxib, rofecoxibum, Vioxx |
| Definition: | A butenolide that is furan-2(5H)-one substituted by a phenyl group at position 3 and by a p-(methylsulfonyl)phenyl group at position 4. A selective cyclooxygenase 2 inhibitor, it was used from 1999 to 2004 for the treatment of ostoarthritis, but was withdrawn following concerns about an associated increased risk of heart attack and stroke. |
| Ontology: | ChEBI [CHEBI:8887] ( EBI ) |
| Publication: | Tiefenbach et al., 2018 |
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