Search Ontology:
ChEBI

rofecoxib

Term ID
CHEBI:8887
Synonyms
  • 3-phenyl-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone
  • 4-[4-(methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone
  • 4-[4-(methylsulfonyl)phenyl]-3-phenylfuran-2(5H)-one
  • Ceoxx
  • rofecoxib
  • rofecoxibum
  • Vioxx
(all 7)
Definition
A butenolide that is furan-2(5H)-one substituted by a phenyl group at position 3 and by a p-(methylsulfonyl)phenyl group at position 4. A selective cyclooxygenase 2 inhibitor, it was used from 1999 to 2004 for the treatment of ostoarthritis, but was withdrawn following concerns about an associated increased risk of heart attack and stroke.
References
(all 14)
Ontology
ChEBI  ( EBI )
Relationships
Phenotype
Phenotype resulting from rofecoxib
Phenotype where environments contain rofecoxib
Phenotype modified by environments containing rofecoxib
No data available
Phenotype affecting rofecoxib
Human Disease Model