| ZFIN ID: ZDB-EXP-230816-1 |
Experiment Conditions Description: chemical treatment by injection: lipopolysaccharide, chemical treatment by environment: bethanechol, chemical treatment by environment: numidargistat
| chemical treatment by injection: lipopolysaccharide |
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| Name: | chemical treatment by injection |
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| Synonyms: | |
| Definition: | Chemical treatment in which the chemical is injected into the zebrafish. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000237] |
| Name: | lipopolysaccharide |
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| Synonyms: | Lipopolysaccharide, lipopolysaccharides, LPS |
| Definition: | Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria). |
| Ontology: | ChEBI [CHEBI:16412] ( EBI ) |
| chemical treatment by environment: bethanechol |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | bethanechol |
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| Synonyms: | (2-hydroxypropyl)trimethylammonium carbamate, 2-(carbamoyloxy)-N,N,N-trimethylpropan-1-aminium, 2-carbamoyloxypropyl-trimethylazanium, amidopropyldimethylbetaine, Bethanechol, carbamoyl-beta-methylcholine, carbamyl-beta-methylcholine |
| Definition: | The carbamic acid ester of 2-methylcholine. A slowly hydrolysed muscarinic agonist with no nicotinic effects, it is used as its chloride salt to increase smooth muscle tone, as in the gastrointestinal tract following abdominal surgery, treatment of gastro-oesophageal reflux disease, and as an alternative to catheterisation in the treatment of non-obstructive urinary retention. |
| Ontology: | ChEBI [CHEBI:3084] ( EBI ) |
| chemical treatment by environment: numidargistat |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | numidargistat |
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| Synonyms: | (3R,4S)-1-L-alanyl-3-amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic acid, (3R,4S)-3-amino-1-[(2S)-2-aminopropanoyl]-4-(3-boronopropyl)pyrrolidine-3-carboxylic acid, CB 1158, CB-1158, CB1158, INCB 001158, INCB-001158, INCB001158, numidargistat, numidargistatum |
| Definition: | An aminopyrrolidine that is pyrrolidine substituted by (2S)-2-aminopropanoyl, amino, carboxy, and 3-boronopropyl groups at positions 1, 3, 3, and 4 (the 3R,4S-stereoisomer). It is a selective arginase inhibitor being developed by Calithera Biosciences for the treatment of solid tumours. |
| Ontology: | ChEBI [CHEBI:195556] ( EBI ) |
| Publication: | Chen et al., 2022 |
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