numidargistat

Term ID

CHEBI:195556

Synonyms

(3R,4S)-1-L-alanyl-3-amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic acid
(3R,4S)-3-amino-1-[(2S)-2-aminopropanoyl]-4-(3-boronopropyl)pyrrolidine-3-carboxylic acid
CB 1158
CB-1158
CB1158
INCB 001158
INCB-001158
INCB001158
numidargistat
numidargistatum

Definition

An aminopyrrolidine that is pyrrolidine substituted by (2S)-2-aminopropanoyl, amino, carboxy, and 3-boronopropyl groups at positions 1, 3, 3, and 4 (the 3R,4S-stereoisomer). It is a selective arginase inhibitor being developed by Calithera Biosciences for the treatment of solid tumours.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: amino monocarboxylic acid aminopyrrolidine boronic acids N-acylpyrrolidine primary amino compound ... Show All 6 Terms

amino monocarboxylic acid aminopyrrolidine boronic acids N-acylpyrrolidine primary amino compound pyrrolidinecarboxylic acid Show first 5 Terms
has_role: antineoplastic agent EC 3.5.3.1 (arginase) inhibitor immunomodulator

antineoplastic agent EC 3.5.3.1 (arginase) inhibitor immunomodulator Show first 5 Terms

Phenotype

Phenotype resulting from numidargistat

Phenotype where environments contain numidargistat

Phenotype modified by environments containing numidargistat

Human Disease / Model Data

Citations