numidargistat

Term ID

CHEBI:195556

Synonyms

• (3R,4S)-1-L-alanyl-3-amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic acid
• (3R,4S)-3-amino-1-[(2S)-2-aminopropanoyl]-4-(3-boronopropyl)pyrrolidine-3-carboxylic acid
• CB 1158
• CB-1158
• CB1158
• INCB 001158
• INCB-001158
• INCB001158
• numidargistat
• numidargistatum

Definition

An aminopyrrolidine that is pyrrolidine substituted by (2S)-2-aminopropanoyl, amino, carboxy, and 3-boronopropyl groups at positions 1, 3, 3, and 4 (the 3R,4S-stereoisomer). It is a selective arginase inhibitor being developed by Calithera Biosciences for the treatment of solid tumours.

References

• cas:2095732-06-0
• drugbank:DB15286
• kegg.drug:D11792
• pubmed:29254508
• pubmed:29326017
• pubmed:32292546
• pubmed:32647818
• pubmed:32828425
• pubmed:34359992
• pubmed:35759868
• pubmed:36172163
• pubmed:36696484
• pubmed:36727849

Ontology

ChEBI  ( EBI )