| ZFIN ID: ZDB-EXP-230215-1 |
Experiment Conditions Description: chemical treatment by environment: topotecan
| chemical treatment by environment: topotecan |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | topotecan |
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| Synonyms: | (4S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 9-[(dimethylamino)methyl]-10-hydroxy-(4S)-camptothecin, Topotecan, topotecane, topotecanum |
| Definition: | A pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks. |
| Ontology: | ChEBI [CHEBI:63632] ( EBI ) |
| Publication: | Jing et al., 2020 |
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