topotecan

Term ID

CHEBI:63632

Synonyms

• (4S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• 9-[(dimethylamino)methyl]-10-hydroxy-(4S)-camptothecin
• topotecan
• topotecane
• topotecanum

Definition

A pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks.

References

• cas:123948-87-8
• drugbank:DB01030
• kegg.compound:C11158
• kegg.drug:D08618
• lincs.smallmolecule:LSM-5662
• patent:EP321122
• pdb-ccd:TTC
• pubmed:20574789
• pubmed:21255983
• pubmed:21352915
• pubmed:21910214
• pubmed:22028494
• pubmed:22075006
• pubmed:22136714
• pubmed:22190039
• reaxys:4279441
• wikipedia.en:Topotecan

Ontology

ChEBI  ( EBI )

Resources

CTD