Search Ontology:
ChEBI

topotecan

Term ID
CHEBI:63632
Synonyms
  • (4S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
  • 9-[(dimethylamino)methyl]-10-hydroxy-(4S)-camptothecin
  • Topotecan
  • topotecane
  • topotecanum
Definition
A pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks.
References
Ontology
ChEBI  ( EBI )
Resources
CTD
Relationships
is a type of
has_role
Phenotype
Phenotype resulting from topotecan
Phenotype where environments contain topotecan
Phenotype modified by environments containing topotecan
Human Disease Model
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