| ZFIN ID: ZDB-EXP-211026-17 |
Experiment Conditions Description: chemical treatment by injection: amyloid-beta, chemical treatment by environment: 2-methyl-6-(phenylethynyl)pyridine
| chemical treatment by injection: amyloid-beta |
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| Name: | chemical treatment by injection |
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| Synonyms: | |
| Definition: | Chemical treatment in which the chemical is injected into the zebrafish. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000237] |
| Name: | amyloid-beta |
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| Synonyms: | amyloid beta, beta amyloid, beta-amyloid, beta-amyloids |
| Definition: | A peptide of 36-43 amino acids that is processed from the amyloid precursor protein. Appears to be the main constituent of amyloid plaques (deposits found in the brains of Alzheimer's disease patients). |
| Ontology: | ChEBI [CHEBI:64645] ( EBI ) |
| chemical treatment by environment: 2-methyl-6-(phenylethynyl)pyridine |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | 2-methyl-6-(phenylethynyl)pyridine |
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| Synonyms: | 2-methyl-6-(phenylethynyl)pyridine, 6-Methyl-2-(phenylethynyl)pyridine, MPEP |
| Definition: | A methylpyridine that coinsists of 2-methylp[yridine bearing an additional phenylethynyl group at position 6. Potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw. |
| Ontology: | ChEBI [CHEBI:64159] ( EBI ) |
| Publication: | Özcan et al., 2020 |
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