Search Ontology:
ChEBI
2-methyl-6-(phenylethynyl)pyridine
- Term ID
- CHEBI:64159
- Synonyms
-
- 2-methyl-6-(phenylethynyl)pyridine
- 6-Methyl-2-(phenylethynyl)pyridine
- MPEP
- Definition
- A methylpyridine that coinsists of 2-methylp[yridine bearing an additional phenylethynyl group at position 6. Potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw.
- References
-
- cas:219911-35-0
- lincs.smallmolecule:LSM-4678
- pubmed:20579001
- pubmed:21069781
- pubmed:21255635
- pubmed:21656124
- pubmed:21833506
- pubmed:21896278
- pubmed:21964032
- pubmed:21971021
- pubmed:22034224
- pubmed:22079159
- pubmed:22172929
- pubmed:22261382
- pubmed:22267204
- reaxys:140513
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from 2-methyl-6-(phenylethynyl)pyridine
Phenotype where environments contain 2-methyl-6-(phenylethynyl)pyridine
Phenotype modified by environments containing 2-methyl-6-(phenylethynyl)pyridine
Phenotype affecting 2-methyl-6-(phenylethynyl)pyridine
Human Disease Model