| ZFIN ID: ZDB-EXP-201026-15 |
Experiment Conditions Description: high cholesterol, chemical treatment by environment: ibrutinib
| high cholesterol |
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| Name: | high cholesterol |
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| Synonyms: | |
| Definition: | Cholesterol content condition in which the amount of cholesterol in the diet is elevated. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000119] |
| chemical treatment by environment: ibrutinib |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | ibrutinib |
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| Synonyms: | 1-{(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one, ibrutinib, ibrutinibum, IMBRUVICA, PCI 32765, PCI-32765, PCI32765 |
| Definition: | A member of the class of acrylamides that is (3R)-3-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine in which the piperidine nitrogen is replaced by an acryloyl group. A selective and covalent inhibitor of the enzyme Bruton's tyrosine kinase, it is used for treatment of B-cell malignancies. |
| Ontology: | ChEBI [CHEBI:76612] ( EBI ) |
| Publication: | Misselbeck et al., 2019 |
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