Search Ontology:
ChEBI
ibrutinib
- Term ID
- CHEBI:76612
- Synonyms
-
- 1-{(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one
- ibrutinib
- ibrutinibum
- IMBRUVICA
- PCI 32765
- PCI-32765
- PCI32765
- Definition
- A member of the class of acrylamides that is (3R)-3-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine in which the piperidine nitrogen is replaced by an acryloyl group. A selective and covalent inhibitor of the enzyme Bruton's tyrosine kinase, it is used for treatment of B-cell malignancies.
- References
-
- cas:936563-96-1
- drugcentral:4810
- kegg.drug:D10223
- patent:US2008076921
- patent:US2012053189
- patent:US20130178483
- patent:US2013079327
- patent:US2013178483
- pubmed:22180443
- pubmed:22975686
- pubmed:23045577
- pubmed:23296407
- pubmed:23360303
- pubmed:23425038
- pubmed:23619564
- pubmed:23656200
- pubmed:23672610
- pubmed:23717217
- pubmed:23782158
- pubmed:23886836
- pubmed:23915749
- pubmed:23940282
- pubmed:23958373
- pubmed:23962569
- pubmed:24083545
- pubmed:24111579
- pubmed:24156429
- pubmed:24270740
- pubmed:24307721
- pubmed:24311722
- reaxys:13102252
- wikipedia.en:Ibrutinib
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from ibrutinib
Phenotype where environments contain ibrutinib
Phenotype modified by environments containing ibrutinib
Phenotype affecting ibrutinib
Human Disease Model