| ZFIN ID: ZDB-EXP-200512-1 |
Experiment Conditions Description: perforation: retina, chemical treatment: DAPT
| perforation: retina |
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| Name: | perforation |
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| Synonyms: | |
| Definition: | Experimental condition in which a hole or break in the membranes of an organ or structure of the body is created. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000178] |
| Name: | retina |
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| Synonyms: | retinas |
| Definition: | Multi-tissue structure that contains the retinal neural layer and the retinal pigmented epithelium, and develops from the optic cup. |
| Ontology: | Anatomy Ontology [ZFA:0000152] |
| chemical treatment: DAPT |
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| Name: | chemical treatment |
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| Synonyms: | |
| Definition: | Experimental condition in which the fish is treated with a chemical substance. This treatment could be administered by adding the chemical substance to the tank water, injections, or by consumption. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000111] |
| Name: | DAPT |
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| Synonyms: | gamma-secretase inhibitor IX, GSI-IX, tert-butyl (2S)-({N-[(3,5-difluorophenyl)acetyl]-L-alanyl}amino)(phenyl)acetate, tert-butyl (2S)-2-[[(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoyl]amino]-2-phenylacetate |
| Definition: | A dipeptide consisting of alanylphenylglycine derivatised as a 3,5-difluorophenylacetamide at the amino terminal and a tert-butyl ester at the carboxy terminal. It is a gamma-secretase inhibitor. |
| Ontology: | ChEBI [CHEBI:86193] ( EBI ) |
| Publication: | Mitra et al., 2019 |
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