| ZFIN ID: ZDB-EXP-171009-2 |
Experiment Conditions Description: chemical treatment by injection: trametinib, chemical treatment by injection: CBL0137
| chemical treatment by injection: trametinib |
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| Name: | chemical treatment by injection |
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| Synonyms: | |
| Definition: | Chemical treatment in which the chemical is injected into the zebrafish. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000237] |
| Name: | trametinib |
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| Synonyms: | GSK 1120212, JTP 74057, N-(3-{3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide, trametinib, trametinibum |
| Definition: | A pyridopyrimidine that is used (as its dimethyl sulfoxide addition compound) for the treatment of patients with unresectable or metastatic melanoma with BRAF V600E or V600K mutations, and who have not received prior BRAF inhibitor treatment. |
| Ontology: | ChEBI [CHEBI:75998] ( EBI ) |
| chemical treatment by injection: CBL0137 |
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| Name: | chemical treatment by injection |
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| Synonyms: | |
| Definition: | Chemical treatment in which the chemical is injected into the zebrafish. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000237] |
| Name: | CBL0137 |
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| Synonyms: | 1,1'-{9-[2-(isopropylamino)ethyl]-9H-carbazole-3,6-diyl}diethanone, 1,1'-{9-[2-(propan-2-ylamino)ethyl]-9H-carbazole-3,6-diyl}diethanone, 3,6-diacetyl-9-(2-isopropylethyl)-9H-carbazole, CBL-0137 free base, CBLC137, Curaxin 137, Curaxin-137 |
| Definition: | A member of the class of carbazoles that is 9H-carbazole which is substituted by acetyl groups at positions 3 and 6, and by a 2-isopropylethyl group on the nitrogen atom (position 9). It is a modulator of histone chaperone FACT (FAcilitates Chromatin Transcription) - interaction of CBL0137 with the FACT complex results in simultaneous NF-kappa beta suppression, Heat Shock Transcription Factor 1 (HSF1) suppression and p53 activation - and shows antitumour effects in animal models of various cancers. |
| Ontology: | ChEBI [CHEBI:138650] ( EBI ) |
| Publication: | Zhang et al., 2017 |
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