CBL0137

Term ID

CHEBI:138650

Synonyms

• 1,1'-{9-[2-(isopropylamino)ethyl]-9H-carbazole-3,6-diyl}diethanone
• 1,1'-{9-[2-(propan-2-ylamino)ethyl]-9H-carbazole-3,6-diyl}diethanone
• 3,6-diacetyl-9-(2-isopropylethyl)-9H-carbazole
• CBL-0137 free base
• Curaxin-137

Definition

A member of the class of carbazoles that is 9H-carbazole which is substituted by acetyl groups at positions 3 and 6, and by a 2-isopropylethyl group on the nitrogen atom (position 9). It is a modulator of histone chaperone FACT (FAcilitates Chromatin Transcription) - interaction of CBL0137 with the FACT complex results in simultaneous NF-κ β suppression, Heat Shock Transcription Factor 1 (HSF1) suppression and p53 activation - and shows antitumour effects in animal models of various cancers.

References

• cas:1197996-80-7
• patent:WO2013148864
• pmc:PMC4903394
• pubmed:25402820
• pubmed:26537256
• pubmed:26921329
• pubmed:27370399
• pubmed:27650817
• pubmed:27680682
• pubmed:28480210
• reaxys:24576552

Ontology

ChEBI  ( EBI )