| ZFIN ID: ZDB-EXP-171009-1 |
Experiment Conditions Description: chemical treatment by injection: CBL0137
| chemical treatment by injection: CBL0137 |
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| Name: | chemical treatment by injection |
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| Synonyms: | |
| Definition: | Chemical treatment in which the chemical is injected into the zebrafish. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000237] |
| Name: | CBL0137 |
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| Synonyms: | 1,1'-{9-[2-(isopropylamino)ethyl]-9H-carbazole-3,6-diyl}diethanone, 1,1'-{9-[2-(propan-2-ylamino)ethyl]-9H-carbazole-3,6-diyl}diethanone, 3,6-diacetyl-9-(2-isopropylethyl)-9H-carbazole, CBL-0137 free base, CBLC137, Curaxin 137, Curaxin-137 |
| Definition: | A member of the class of carbazoles that is 9H-carbazole which is substituted by acetyl groups at positions 3 and 6, and by a 2-isopropylethyl group on the nitrogen atom (position 9). It is a modulator of histone chaperone FACT (FAcilitates Chromatin Transcription) - interaction of CBL0137 with the FACT complex results in simultaneous NF-kappa beta suppression, Heat Shock Transcription Factor 1 (HSF1) suppression and p53 activation - and shows antitumour effects in animal models of various cancers. |
| Ontology: | ChEBI [CHEBI:138650] ( EBI ) |
| Publication: | Zhang et al., 2017 |
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