ZFIN ID: ZDB-EXP-120802-3
Experiment Conditions Description: chemical treatment: alvocidib
chemical treatment: alvocidib
Name: chemical treatment
Synonyms:
Definition: Experimental condition in which the fish is treated with a chemical substance. This treatment could be administered by adding the chemical substance to the tank water, injections, or by consumption.
Ontology: Zebrafish Environment Condition Ontology [ZECO:0000111]
Name: alvocidib
Synonyms: (-)-cis-5,7-dihydroxy-2-(2-chlorophenyl)-8-(4-(3-hydroxy-1-methyl)piperidinyl)-4H-1-benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one, alvocidib, alvocidibum, Flavopiridol, HMR 1274, HMR-1274, L 86-8275, L 868275, L-868275, L86-8275
Definition: A synthetic dihydroxyflavone that is 5,7-dihydroxyflavone which is substituted by a 3-hydroxy-1-methylpiperidin-4-yl group at position 8 and by a chlorine at the 2' position (the (-)-3S,4R stereoisomer). A cyclin-dependent kinase 9 (CDK9) inhibitor, it has been studied for the treatment of acute myeloid leukaemia, arthritis and atherosclerotic plaque formation.
Ontology: ChEBI [CHEBI:47344]  ( EBI )
Publication: Kim et al., 2012