alvocidib

Term ID

CHEBI:47344

Synonyms

• (-)-cis-5,7-dihydroxy-2-(2-chlorophenyl)-8-(4-(3-hydroxy-1-methyl)piperidinyl)-4H-1-benzopyran-4-one
• 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one
• alvocidib
• alvocidibum
• Flavopiridol
• HMR 1274
• HMR-1274
• L 86-8275
• L 868275
• L-868275
• L86-8275

Definition

A synthetic dihydroxyflavone that is 5,7-dihydroxyflavone which is substituted by a 3-hydroxy-1-methylpiperidin-4-yl group at position 8 and by a chlorine at the 2' position (the (−)-3S,4R stereoisomer). A cyclin-dependent kinase 9 (CDK9) inhibitor, it has been studied for the treatment of acute myeloid leukaemia, arthritis and atherosclerotic plaque formation.

References

• cas:146426-40-6
• drugbank:DB03496
• kegg.drug:D09868
• lincs.smallmolecule:LSM-1011
• patent:EP241003
• patent:US4900727
• pdb-ccd:CPB
• pubmed:10441105
• pubmed:1279187
• pubmed:18209094
• pubmed:21541623
• pubmed:23959599
• pubmed:25118834
• pubmed:25216351
• pubmed:25351763
• pubmed:25623777
• pubmed:25860066
• pubmed:25989942
• pubmed:26022709
• pubmed:26521988
• pubmed:26599132
• pubmed:8002990
• pubmed:9269999
• pubmed:9815683
• wikipedia.en:Alvocidib

Ontology

ChEBI  ( EBI )