| ZFIN ID: ZDB-EXP-260318-7 |
Experiment Conditions Description: in vitro culture: blastomere, chemical treatment by environment: forskolin, chemical treatment by environment: N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide
| in vitro culture: blastomere |
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| Name: | in vitro culture |
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| Synonyms: | |
| Definition: | Experimental condition in which components of the fish have been removed and are maintained separately. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000143] |
| Name: | blastomere |
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| Synonyms: | blastomeres |
| Definition: | Cell that arises during cleavage and is partially cleaved, and located at the blastodisc margin prior to collectively forming the yolk syncytial layer (YSL) in the midblastula. |
| Ontology: | Anatomy Ontology [ZFA:0000093] |
| chemical treatment by environment: forskolin |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | forskolin |
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| Synonyms: | (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxododecahydro-1H-benzo[f]chromen-5-yl acetate, 7beta-acetoxy-8,13-epoxy-1alpha,6beta,9alpha-trihydroxylabd-14-en-11-one, Coleonol, Coleonolk, colforsin, colforsina, colforsine, colforsinum, Forskolin |
| Definition: | A labdane diterpenoid isolated from the Indian Coleus plant. |
| Ontology: | ChEBI [CHEBI:42471] ( EBI ) |
| chemical treatment by environment: N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide |
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| Synonyms: | H 89, H-89, H89, N-(2-{[3-(4-bromophenyl)prop-2-en-1-yl]amino}ethyl)isoquinoline-5-sulfonamide, N-[2-(4-bromocinnamylamino)ethyl]-5-isoquinoline sulfonamide, N-[2-[[3-(4-bromophenyl)-2-propen-1-yl]amino]ethyl]-5-isoquinolinesulfonamide, protein kinase inhibitor H89 |
| Definition: | A member of the class of isoquinolines that is the sulfonamide obtained by formal condensation of the sulfo group of isoquinoline-5-sulfonic acid with the primary amino group of N1-[3-(4-bromophenyl)prop-2-en-1-yl]ethane-1,2-diamine. It is a protein kinase A inhibitor. |
| Ontology: | ChEBI [CHEBI:47495] ( EBI ) |
| Publication: | Niu et al., 2024 |
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