| ZFIN ID: ZDB-EXP-260310-6 |
Experiment Conditions Description: chemical treatment by environment: pexidartinib, physical alteration: retina
| chemical treatment by environment: pexidartinib |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | pexidartinib |
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| Synonyms: | 5-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-N-{[6-(trifluoromethyl)pyridin-3-yl]methyl}pyridin-2-amine, CML-261, pexidartinib, pexidartinibum, PLX-3397, PLX3397, Turalio |
| Definition: | A pyrrolopyridine that is 5-chloro-1H-pyrrolo[2,3-b]pyridine which is substituted by a [6-({[6-(trifluoromethyl)pyridin-3-yl]methyl}amino)pyridin-3-yl]methyl group at position 3. It is a potent multi-targeted receptor tyrosine kinase inhibitor of CSF-1R, KIT, and FLT3 (IC50 of 20 nM, 10 nM and 160 nM, respectively). Approved by the FDA for the treatment of adult patients with symptomatic tenosynovial giant cell tumor (TGCT). |
| Ontology: | ChEBI [CHEBI:145373] ( EBI ) |
| physical alteration: retina |
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| Name: | physical alteration |
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| Synonyms: | |
| Definition: | Experimental condition in which an anatomical structure, cell, or organ has sustained targeted physical change, usually through the use of an instrument. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000229] |
| Name: | retina |
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| Synonyms: | retinas |
| Definition: | Multi-tissue structure that contains the retinal neural layer and the retinal pigmented epithelium, and develops from the optic cup. |
| Ontology: | Anatomy Ontology [ZFA:0000152] |
| Publication: | Mitra et al., 2022 |
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