Search Ontology:
ChEBI
pexidartinib
- Term ID
- CHEBI:145373
- Synonyms
-
- 5-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-N-{[6-(trifluoromethyl)pyridin-3-yl]methyl}pyridin-2-amine
- CML-261
- pexidartinib
- pexidartinibum
- PLX-3397
- PLX3397
- Turalio
- Definition
- A pyrrolopyridine that is 5-chloro-1H-pyrrolo[2,3-b]pyridine which is substituted by a [6-({[6-(trifluoromethyl)pyridin-3-yl]methyl}amino)pyridin-3-yl]methyl group at position 3. It is a potent multi-targeted receptor tyrosine kinase inhibitor of CSF-1R, KIT, and FLT3 (IC50 of 20 nM, 10 nM and 160 nM, respectively). Approved by the FDA for the treatment of adult patients with symptomatic tenosynovial giant cell tumor (TGCT).
- References
-
- cas:1029044-16-3
- drugbank:DB12978
- kegg.drug:D11270
- pdb-ccd:P31
- pmc:PMC6012252
- pubmed:26222558
- pubmed:26449250
- pubmed:30002809
- pubmed:30628737
- pubmed:30825104
- pubmed:30926949
- pubmed:31167689
- pubmed:31213500
- pubmed:31229240
- pubmed:31240240
- pubmed:31258629
- pubmed:31602563
- pubmed:31696640
- wikipedia.en:Pexidartinib
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from pexidartinib
Phenotype where environments contain pexidartinib
Phenotype modified by environments containing pexidartinib
Phenotype affecting pexidartinib
Human Disease Model