pexidartinib

Term ID

CHEBI:145373

Synonyms

5-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-N-{[6-(trifluoromethyl)pyridin-3-yl]methyl}pyridin-2-amine
CML-261
pexidartinib
pexidartinibum
PLX-3397
PLX3397
Turalio

Definition

A pyrrolopyridine that is 5-chloro-1H-pyrrolo[2,3-b]pyridine which is substituted by a [6-({[6-(trifluoromethyl)pyridin-3-yl]methyl}amino)pyridin-3-yl]methyl group at position 3. It is a potent multi-targeted receptor tyrosine kinase inhibitor of CSF-1R, KIT, and FLT3 (IC50 of 20 nM, 10 nM and 160 nM, respectively). Approved by the FDA for the treatment of adult patients with symptomatic tenosynovial giant cell tumor (TGCT).

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: aminopyridine organochlorine compound organofluorine compound pyrrolopyridine secondary amino compound

aminopyridine organochlorine compound organofluorine compound pyrrolopyridine secondary amino compound Show first 5 Terms
has_role: antineoplastic agent EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor

antineoplastic agent EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from pexidartinib

Phenotype where environments contain pexidartinib

Phenotype modified by environments containing pexidartinib

Human Disease / Model Data

Citations