| ZFIN ID: ZDB-EXP-260109-4 |
Experiment Conditions Description: chemical treatment by environment: all-trans-retinoic acid, chemical treatment by environment: rimonabant
| chemical treatment by environment: all-trans-retinoic acid |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | all-trans-retinoic acid |
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| Synonyms: | (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)nona-2,4,6,8-tetraenoic acid, (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid, (all-E)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid, 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexene-1-yl)-2,4,6,8-nonatetraenoic acid, 3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-all-trans-tetraenoic acid, 3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2E,4E,6E,8E-tetraenoic acid, Acide retinoique (French), AGN 100335, all-(E)-retinoic acid, all-trans retinoic acid, all-trans-beta-Retinoic acid, all-trans-retinoic acid, all-trans-tretinoin, all-trans-vitamin A acid, all-trans-vitamin A1 acid, Altreno, Atralin, Avita, beta-Retinoic acid, Betarretin, Biacna, Cordes vas, Dermairol, Refissa, Renova, Retin-A, retinoic acid, Retisol-A, Ro 1-5488, Stieva-A, trans-retinoic acid, Tretin M, tretinoin, tretinoina, tretinoine, tretinoinum, Tri-luma, Veltin, Vesanoid, vitamin A acid |
| Definition: | A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry. |
| Ontology: | ChEBI [CHEBI:15367] ( EBI ) |
| chemical treatment by environment: rimonabant |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | rimonabant |
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| Synonyms: | 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide, 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide, A 281, Acomplia, N-(1-piperidinyl)-1-(2,4-dichlorophenyl)-4-methyl-5-(4-chlorophenyl)-1H-pyrazole-3-carboxamide, rimonabant, rimonabantum, SR 141716, SR141716, Zimulti |
| Definition: | A carbohydrazide obtained by formal condensation of the carboxy group of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. It is a potent and selective cannabinoid receptor 1 (CB1R) antagonist. Besides its antagonistic properties, numerous studies have shown that, at micromolar concentrations rimonabant behaves as an inverse agonist at CB1 receptors. The drug was the first selective CB1 antagonist/inverse agonist introduced into clinical practice to treat obesity and metabolic-related disorders. It was later withdrawn from market due to CNS-related adverse effects including depression and suicidal ideation. |
| Ontology: | ChEBI [CHEBI:34967] ( EBI ) |
| Publication: | Fraher et al., 2021 |
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