Search Ontology:
ChEBI
rimonabant
- Term ID
- CHEBI:34967
- Synonyms
-
- 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide
- 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide
- A 281
- Definition
- A carbohydrazide obtained by formal condensation of the carboxy group of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. It is a potent and selective cannabinoid receptor 1 (CB1R) antagonist. Besides its antagonistic properties, numerous studies have shown that, at micromolar concentrations rimonabant behaves as an inverse agonist at CB1 receptors. The drug was the first selective CB1 antagonist/inverse agonist introduced into clinical practice to treat obesity and metabolic-related disorders. It was later withdrawn from market due to CNS-related adverse effects including depression and suicidal ideation.
- References
-
- CAS:168273-06-1
- Chemspider:94641
- DrugBank:DB06155
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from rimonabant
Phenotype where environments contain rimonabant
Phenotype modified by environments containing rimonabant
Phenotype affecting rimonabant
Human Disease Model