| Name: |
6-aminonicotinamide |
| Synonyms: |
2-amino-5-carbamoylpyridine,
6-amino-3-pyridinecarboxamide,
6-aminonicotinamide,
6-aminonicotinic acid amide,
6-Aminonikotinsaeureamid,
6-AN,
6-ANA,
SR 4388
|
| Definition: |
A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 6-aminonicotinic acid with ammonia. An inhibitor of the NADP(+)-dependent enzyme, 6-phosphogluconate dehydrogenase, it interferes with glycolysis, resulting in ATP depletion and synergizes with DNA-crosslinking chemotherapy drugs, such as cisplatin, in killing cancer cells. |
| Ontology: |
ChEBI [CHEBI:74514]
(
EBI
)
|
