Search Ontology:
ChEBI
6-aminonicotinamide
- Term ID
- CHEBI:74514
- Synonyms
-
- 2-amino-5-carbamoylpyridine
- 6-amino-3-pyridinecarboxamide
- 6-aminonicotinamide
- 6-aminonicotinic acid amide
- 6-Aminonikotinsaeureamid
- 6-AN
- 6-ANA
- SR 4388
- Definition
- A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 6-aminonicotinic acid with ammonia. An inhibitor of the NADP+-dependent enzyme, 6-phosphogluconate dehydrogenase, it interferes with glycolysis, resulting in ATP depletion and synergizes with DNA-crosslinking chemotherapy drugs, such as cisplatin, in killing cancer cells.
- References
-
- cas:329-89-5
- metacyc.compound:CPD-9571
- pubmed:125068
- pubmed:145497
- pubmed:152349
- pubmed:155198
- pubmed:2948367
- pubmed:3156443
- pubmed:6236288
- pubmed:6445393
- pubmed:9516960
- reaxys:116042
- Ontology
- ChEBI ( EBI )
- Resources
- CTD
Phenotype
Phenotype resulting from 6-aminonicotinamide
Phenotype where environments contain 6-aminonicotinamide
Phenotype modified by environments containing 6-aminonicotinamide
Phenotype affecting 6-aminonicotinamide
Human Disease Model