| ZFIN ID: ZDB-EXP-250521-4 |
Experiment Conditions Description: chemical treatment by environment: sapanisertib
| chemical treatment by environment: sapanisertib |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | sapanisertib |
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| Synonyms: | 3-(2-amino-1,3-benzoxazol-5-yl)-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, 3-(2-amino-5-benzoxazolyl)-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, 5-(4-amino-1-propan-2-yl-3-pyrazolo[3,4-d]pyrimidinyl)-1,3-benzoxazol-2-amine, CB-228, FTH-003, INK 128, INK-128, INK128, MLN 0128, MLN-0128, MLN0128, sapanisertib, sapanisertibum, TAK 228, TAK-228, TAK228 |
| Definition: | A 1,3-benzoxazole substituted by amino and 4-amino-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl groups at positions 2 and 5, respectively. It is a ATP-competitive inhibitor of mTORC1 and mTORC2 that exhibits antineoplastic activity. |
| Ontology: | ChEBI [CHEBI:91450] ( EBI ) |
| Publication: | Ma et al., 2025 |
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