sapanisertib

Term ID

CHEBI:91450

Synonyms

3-(2-amino-1,3-benzoxazol-5-yl)-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
3-(2-amino-5-benzoxazolyl)-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
5-(4-amino-1-propan-2-yl-3-pyrazolo[3,4-d]pyrimidinyl)-1,3-benzoxazol-2-amine
CB-228
FTH-003
INK 128
INK-128
INK128
MLN 0128
MLN-0128
MLN0128
sapanisertib
sapanisertibum
TAK 228
TAK-228
TAK228

Definition

A 1,3-benzoxazole substituted by amino and 4-amino-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl groups at positions 2 and 5, respectively. It is a ATP-competitive inhibitor of mTORC1 and mTORC2 that exhibits antineoplastic activity.

References

cas:1224844-38-5
drugbank:DB11836
hmdb:HMDB0244472
kegg.drug:D11183
lincs.smallmolecule:LSM-1206
pdb-ccd:FE5
pmc:PMC5692652
pmc:PMC8168110
pubmed:22367541
pubmed:28601972
pubmed:29464110
pubmed:31160383
pubmed:31749911
pubmed:32257249
pubmed:32414750
pubmed:32913286
pubmed:33235998
pubmed:34204960
pubmed:34843044
pubmed:35142090
pubmed:35171658
pubmed:35412171
pubmed:35484114
pubmed:35843739
pubmed:36240971
pubmed:36264382
pubmed:36323854
pubmed:37072571
pubmed:37372982
pubmed:37394756
pubmed:37491309
pubmed:37839313
pubmed:37960985
pubmed:38126764
pubmed:38391917
pubmed:38400671
pubmed:38475728
pubmed:38626436
pubmed:38672538
pubmed:38905731
wikipedia.en:Sapanisertib

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from sapanisertib

Phenotype where environments contain sapanisertib

Phenotype modified by environments containing sapanisertib

Phenotype affecting sapanisertib

Human Disease Model