| ZFIN ID: ZDB-EXP-191127-8 |
Experiment Conditions Description: chemical treatment by environment: 5-fluorouracil, cancer xenotransplantation, chemical treatment by environment: tyrosine kinase inhibitor
| chemical treatment by environment: 5-fluorouracil |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | 5-fluorouracil |
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| Synonyms: | 5-Fluoracil, 5-fluoropyrimidine-2,4(1H,3H)-dione, 5-Fluoropyrimidine-2,4-dione, 5-fluorouracil, 5-FU, Fluorouracil, fluorouracilo, fluorouracilum |
| Definition: | A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth. |
| Ontology: | ChEBI [CHEBI:46345] ( EBI ) |
| cancer xenotransplantation |
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| Name: | cancer xenotransplantation |
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| Synonyms: | |
| Definition: | Xenotransplantation condition in which cancer cells are injected or grafted into the zebrafish. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000236] |
| chemical treatment by environment: tyrosine kinase inhibitor |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | tyrosine kinase inhibitor |
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| Synonyms: | protein tyrosine kinase inhibitor, protein tyrosine kinase inhibitors, TKI inhibitor, TKI inhibitors, tyrosine kinase inhibitors, tyrphostin, tyrphostins |
| Definition: | Any protein kinase inhibitor that interferes with the action of tyrosine kinase. |
| Ontology: | ChEBI [CHEBI:38637] ( EBI ) |
| Publication: | Xu et al., 2019 |
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