Search Ontology:
ChEBI

5-fluorouracil

Term ID
CHEBI:46345
Synonyms
  • 5-Fluoracil
  • 5-fluoropyrimidine-2,4(1H,3H)-dione
  • 5-Fluoropyrimidine-2,4-dione
  • 5-Fluorouracil
  • 5-FU
  • Fluorouracil
  • fluorouracilo
  • fluorouracilum
Definition
A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
References
Ontology
ChEBI  ( EBI )
Resources
CTD
Relationships
is a type of
has_functional_parent
has_role
Phenotype
Phenotype resulting from 5-fluorouracil
Phenotype where environments contain 5-fluorouracil
Phenotype modified by environments containing 5-fluorouracil
Human Disease Model
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