| ZFIN ID: ZDB-EXP-171113-3 |
Experiment Conditions Description: chemical treatment by environment: golgicide A
| chemical treatment by environment: golgicide A |
|---|
| Name: | chemical treatment by environment |
|---|---|
| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | golgicide A |
|---|---|
| Synonyms: | 6,8-Difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline, GCA |
| Definition: | A diastereoisomeric mixture comprising racemic cis- and racemic trans-goglioside A in a 10:1 ratio. It is a potent and rapidly reversible GBF1 (Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1) inhibitor. The (3aS,4R,9bR) isomer is the most active (see Bioorg. Med. Chem. Lett., 2012, 22, 5177-5181). |
| Ontology: | ChEBI [CHEBI:139037] ( EBI ) |
| Publication: | Chen et al., 2017 |
|---|