TALEN

TALEN1-esr1

ID

ZDB-TALEN-190206-1

Name

TALEN1-esr1

Previous Names

None

Target

esr1 (1)

Target Sequence 1

5' - GGATATCATTACGGAG - 3'

Target Sequence 2

5' - GAAGAAAGCTTTGCAT - 3'

Disclaimer

Although ZFIN verifies reagent sequence data, we recommend that you conduct independent sequence analysis before ordering any reagent.

Note

None

Genome Resources

None

Target Location

Genome Build: GRCz11Chromosome: 20

Constructs

No data available

Genomic Features

Genomic Feature	Affected Genomic Regions
zf2164	esr1

Expression

Gene expression in Wild Types + TALEN1-esr1

No data available

Phenotype

Phenotype resulting from TALEN1-esr1

No data available

Phenotype of all Fish created by or utilizing TALEN1-esr1

Phenotype	Fish	Conditions	Figures
ovary tsc1b expression decreased amount, abnormal	esr1^{zf2164/zf2164}	standard conditions	Fig. 6 from Chen et al., 2018
female organism sterile, abnormal	esr1^{zf2164/zf2164}	standard conditions	Fig. 3 from Chen et al., 2018
liver vtg2 expression decreased amount, abnormal	esr1^{zf2164/zf2164}	standard conditions	Fig. 4 from Chen et al., 2018
ovary mtor expression increased amount, abnormal	esr1^{zf2164/zf2164}	standard conditions	Fig. 6 from Chen et al., 2018
ovary igf2b expression increased amount, abnormal	esr1^{zf2164/zf2164}	standard conditions	Fig. 6 from Chen et al., 2018
ovary hsd17b1 expression decreased amount, abnormal	esr1^{zf2164/zf2164}	standard conditions	Fig. 5 from Chen et al., 2018
ovary hsd17b3 expression increased amount, abnormal	esr1^{zf2164/zf2164}	standard conditions	Fig. 5 from Chen et al., 2018
liver vtg5 expression decreased amount, abnormal	esr1^{zf2164/zf2164}	standard conditions	Fig. 4 from Chen et al., 2018
female organism 11-oxotestosterone decreased amount, abnormal	esr1^{zf2164/zf2164}	standard conditions	Fig. 5 from Chen et al., 2018
female organism decreased fertility, abnormal	esr1^{zf2164/zf2164}	standard conditions	Fig. 3 from Chen et al., 2018
ovary star expression decreased amount, abnormal	esr1^{zf2164/zf2164}	standard conditions	Fig. 5 from Chen et al., 2018
ovarian follicle absence due to degeneration, abnormal	esr1^{zf2164/zf2164}	standard conditions	Fig. 2 from Chen et al., 2018
liver vtg7 expression decreased amount, abnormal	esr1^{zf2164/zf2164}	standard conditions	Fig. 4 from Chen et al., 2018
female organism increased weight, abnormal	esr1^{zf2164/zf2164}	standard conditions	Fig. 2 from Chen et al., 2018
hypophysis Ab1-lhb labeling decreased amount, abnormal	esr1^{zf2164/zf2164}	standard conditions	Fig. 5 from Chen et al., 2018
ovary fshr expression decreased amount, abnormal	esr1^{zf2164/zf2164}	standard conditions	Fig. 5 from Chen et al., 2018
liver vtg1 expression decreased amount, abnormal	esr1^{zf2164/zf2164}	standard conditions	Fig. 4 from Chen et al., 2018
ovary lhcgr expression decreased amount, abnormal	esr1^{zf2164/zf2164}	standard conditions	Fig. 5 from Chen et al., 2018
liver vtg6 expression decreased amount, abnormal	esr1^{zf2164/zf2164}	standard conditions	Fig. 4 from Chen et al., 2018
ovary cyp11a1.2 expression decreased amount, abnormal	esr1^{zf2164/zf2164}	standard conditions	Fig. 5 from Chen et al., 2018
female organism estradiol increased amount, abnormal	esr1^{zf2164/zf2164}	standard conditions	Fig. 5 from Chen et al., 2018
ovary star expression increased amount, abnormal	esr1^{zf2164/zf2164}	standard conditions	Fig. 5 from Chen et al., 2018
ovary hsd17b3 expression decreased amount, abnormal	esr1^{zf2164/zf2164}	standard conditions	Fig. 5 from Chen et al., 2018
female organism size, abnormal	esr1^{zf2164/zf2164}	standard conditions	Fig. 2 from Chen et al., 2018
ovary fshr expression increased amount, abnormal	esr1^{zf2164/zf2164}	standard conditions	Fig. 5 from Chen et al., 2018
ovary rps6 expression increased amount, abnormal	esr1^{zf2164/zf2164}	standard conditions	Fig. 6 from Chen et al., 2018
ovary degenerate, abnormal	esr1^{zf2164/zf2164}	standard conditions	Fig. 2 from Chen et al., 2018
ovary igf1 expression increased amount, abnormal	esr1^{zf2164/zf2164}	standard conditions	Fig. 6 from Chen et al., 2018
ovary eif4ba expression increased amount, abnormal	esr1^{zf2164/zf2164}	standard conditions	Fig. 6 from Chen et al., 2018
ovary tsc1a expression decreased amount, abnormal	esr1^{zf2164/zf2164}	standard conditions	Fig. 6 from Chen et al., 2018
hypophysis Ab1-fshb labeling decreased amount, abnormal	esr1^{zf2164/zf2164}	standard conditions	Fig. 5 from Chen et al., 2018
ovarian follicle stage IV absence due to degeneration, abnormal	esr1^{zf2164/zf2164}	standard conditions	Fig. 2 from Chen et al., 2018
female organism estradiol decreased amount, abnormal	esr1^{zf2164/zf2164}	standard conditions	Fig. 5 from Chen et al., 2018
ovary cyp19a1a expression increased amount, abnormal	esr1^{zf2164/zf2164}	standard conditions	Fig. 5 from Chen et al., 2018
ovary hsd17b1 expression increased amount, abnormal	esr1^{zf2164/zf2164}	standard conditions	Fig. 5 from Chen et al., 2018
ovary igf2a expression increased amount, abnormal	esr1^{zf2164/zf2164}	standard conditions	Fig. 6 from Chen et al., 2018
liver vtg3 expression decreased amount, abnormal	esr1^{zf2164/zf2164}	standard conditions	Fig. 4 from Chen et al., 2018
liver vtg4 expression decreased amount, abnormal	esr1^{zf2164/zf2164}	standard conditions	Fig. 4 from Chen et al., 2018
ovary cyp19a1a expression decreased amount, abnormal	esr1^{zf2164/zf2164}	standard conditions	Fig. 5 from Chen et al., 2018
ovary tsc2 expression decreased amount, abnormal	esr1^{zf2164/zf2164}	standard conditions	Fig. 6 from Chen et al., 2018
ovarian follicle vitellogenesis decreased occurrence, abnormal	esr1^{zf2164/zf2164}	standard conditions	Fig. 4 from Chen et al., 2018
ovary hsd11b2 expression decreased amount, abnormal	esr1^{zf2164/zf2164}	standard conditions	Fig. 5 from Chen et al., 2018

Citations

Include unpublished citations

Chen, Y., Tang, H., Wang, L., He, J., Guo, Y., Liu, Y., Liu, X., Lin, H. (2018) Fertility Enhancement but Premature Ovarian Failure in esr1-Deficient Female Zebrafish.. Frontiers in endocrinology. 9:567

1 - 1 of 1

Show