TALEN

TALEN5-rb1

ID

ZDB-TALEN-180531-2

Name

TALEN5-rb1

Previous Names

None

Target

rb1 (1)

Target Sequence 1

5' - CCAGTCCACTAACT - 3'

Target Sequence 2

5' - CTCCCATATTCTCCAT - 3'

Disclaimer

Although ZFIN verifies reagent sequence data, we recommend that you conduct independent sequence analysis before ordering any reagent.

Note

None

Genome Resources

None

Target Location

Constructs

No data available

Genomic Features

Genomic Feature	Affected Genomic Regions
sm11	rb1

Expression

Gene expression in Wild Types + TALEN5-rb1

No data available

Phenotype

Phenotype resulting from TALEN5-rb1

No data available

Phenotype of all Fish created by or utilizing TALEN5-rb1

Phenotype	Fish	Conditions	Figures
cysteine-type endopeptidase activity involved in apoptotic process increased process quality, abnormal	rb1^sm11/sm11	control	Fig. 4 from Zhang et al., 2017
whole organism rb1 expression absent, abnormal	rb1^sm11/sm11	control	Fig. 1 from Zhang et al., 2017
thymus rag1 expression decreased amount, abnormal	rb1^sm11/sm11	control	Fig. 2 from Zhang et al., 2017
whole organism casp3a expression increased amount, abnormal	rb1^sm11/sm11	control	Fig. 5 from Zhang et al., 2017
thymus lymphocyte ikzf1 expression decreased amount, abnormal	rb1^sm11/sm11	control	Fig. 2 from Zhang et al., 2017
whole organism e2f1 expression increased amount, abnormal	rb1^sm11/sm11	control	Fig. 5 from Zhang et al., 2017
thymus anatomical region e2f1 expression increased amount, abnormal	rb1^sm11/sm11	control	Fig. 5 from Zhang et al., 2017
thymus anatomical region rag2 expression decreased amount, abnormal	rb1^sm11/sm11	control	Fig. 2 from Zhang et al., 2017
whole organism rag2 expression decreased amount, abnormal	rb1^sm11/sm11	control	Fig. 5 from Zhang et al., 2017
whole organism linc-tcrb expression decreased amount, abnormal	rb1^sm11/sm11	control	Fig. 5 from Zhang et al., 2017
thymus anatomical region casp3a expression increased amount, abnormal	rb1^sm11/sm11	control	Fig. 4 from Zhang et al., 2017
thymus T cell lck expression decreased amount, abnormal	rb1^sm11/sm11	control	Fig. 2 from Zhang et al., 2017
thymus anatomical region cd4-1 expression decreased amount, abnormal	rb1^sm11/sm11	control	Fig. 2 from Zhang et al., 2017
whole organism cd247 expression decreased amount, abnormal	rb1^sm11/sm11	control	Fig. 5 from Zhang et al., 2017
whole organism trac expression decreased amount, abnormal	rb1^sm11/sm11	control	Fig. 5 from Zhang et al., 2017
whole organism decreased life span, abnormal	rb1^sm11/sm11	control	Fig. 1 from Zhang et al., 2017
thymus T cell decreased amount, ameliorated	rb1^sm11/sm11; zf411Tg	chemical treatment by environment: Z-Val-Ala-Asp(OMe)-CH2F	Fig. 4 from Zhang et al., 2017
T cell cell maturation decreased occurrence, abnormal	rb1^sm11/sm11; zf411Tg	control	Fig. 2 from Zhang et al., 2017
thymus T cell decreased amount, abnormal	rb1^sm11/sm11; zf411Tg	control	Fig. 2 , Fig. 4 , Fig. 5 from Zhang et al., 2017
T cell apoptotic process increased occurrence, abnormal	rb1^sm11/sm11; zf411Tg	control	Fig. 3 , Fig. 5 from Zhang et al., 2017
whole organism cd247 expression amount, ameliorated	rb1^sm11/sm11 + MO1-e2f1	control	Fig. 5 from Zhang et al., 2017
whole organism rag2 expression amount, ameliorated	rb1^sm11/sm11 + MO1-e2f1	control	Fig. 5 from Zhang et al., 2017
whole organism casp3a expression amount, ameliorated	rb1^sm11/sm11 + MO1-e2f1	control	Fig. 5 from Zhang et al., 2017
whole organism e2f1 expression amount, ameliorated	rb1^sm11/sm11 + MO1-e2f1	control	Fig. 5 from Zhang et al., 2017
whole organism linc-tcrb expression amount, ameliorated	rb1^sm11/sm11 + MO1-e2f1	control	Fig. 5 from Zhang et al., 2017
whole organism trac expression amount, ameliorated	rb1^sm11/sm11 + MO1-e2f1	control	Fig. 5 from Zhang et al., 2017
T cell apoptotic process occurrence, ameliorated	rb1^sm11/sm11; zf411Tg + MO1-e2f1	control	Fig. 5 from Zhang et al., 2017
thymus T cell decreased amount, ameliorated	rb1^sm11/sm11; zf411Tg + MO1-e2f1	control	Fig. 5 from Zhang et al., 2017
thymus T cell decreased amount, abnormal	tp53^zdf1/zdf1; rb1^sm11/sm11; zf411Tg	control	Fig. 4 from Zhang et al., 2017

Citations