TALEN

TALEN1-foxl2a

ID

ZDB-TALEN-170517-1

Name

TALEN1-foxl2a

Previous Names

TALEN1-FOXL2
TALEN1-foxl2

Target

foxl2a (1)

Target Sequence 1

5' - GCGCAATGATGGCCACCT - 3'

Target Sequence 2

5' - CCATGAGTATCATGCCGT - 3'

Disclaimer

Although ZFIN verifies reagent sequence data, we recommend that you conduct independent sequence analysis before ordering any reagent.

Note

None

Genome Resources

None

Target Location

Constructs

No data available

Genomic Features

Genomic Feature	Affected Genomic Regions
ihb172	foxl2a

Expression

Gene expression in Wild Types + TALEN1-foxl2a

No data available

Phenotype

Phenotype resulting from TALEN1-foxl2a

No data available

Phenotype of all Fish created by or utilizing TALEN1-foxl2a

Phenotype	Fish	Conditions	Figures
oocyte reproductive senescence increased occurrence, abnormal	foxl2a^{ihb172/ihb172} (AB)	standard conditions	Fig. 4 from Yang et al., 2017
optic stalk pax2a expression decreased amount, abnormal	foxl2a^{ihb172/ihb172} (AB)	standard conditions	Fig. 5 from Zhou et al., 2022
midbrain hindbrain boundary wnt1 expression decreased amount, abnormal	foxl2a^{ihb172/ihb172} (AB)	standard conditions	Fig. 6 from Zhou et al., 2022
whole organism wnt1 expression decreased amount, abnormal	foxl2a^{ihb172/ihb172} (AB)	standard conditions	Fig. 5, Fig. 6 from Zhou et al., 2022
ovary sox9a expression increased amount, abnormal	foxl2a^{ihb172/ihb172} (AB)	standard conditions	Fig. 6, Fig. S5 from Yang et al., 2017
midbrain hindbrain boundary neural keel wnt1 expression decreased amount, abnormal	foxl2a^{ihb172/ihb172} (AB)	standard conditions	Fig. 5 from Zhou et al., 2022
midbrain hindbrain boundary neural keel en1b expression decreased amount, abnormal	foxl2a^{ihb172/ihb172} (AB)	standard conditions	Fig. 5 from Zhou et al., 2022
midbrain hindbrain boundary en1b expression decreased amount, abnormal	foxl2a^{ihb172/ihb172} (AB)	standard conditions	Fig. 6 from Zhou et al., 2022
gonad foxl2b expression increased amount, abnormal	foxl2a^{ihb172/ihb172} (AB)	standard conditions	Fig. 9 from Yang et al., 2017
midbrain hindbrain boundary neural keel pax2a expression decreased amount, abnormal	foxl2a^{ihb172/ihb172} (AB)	standard conditions	Fig. 5 from Zhou et al., 2022
whole organism en1b expression decreased amount, abnormal	foxl2a^{ihb172/ihb172} (AB)	standard conditions	Fig. 5, Fig. 6 from Zhou et al., 2022
ovary cyp11a1.1 expression decreased amount, abnormal	foxl2a^{ihb172/ihb172} (AB)	standard conditions	Fig. 7 from Yang et al., 2017
ovary cyp19a1a expression decreased amount, abnormal	foxl2a^{ihb172/ihb172} (AB)	standard conditions	Fig. 6 from Yang et al., 2017
ovary morphology, abnormal	foxl2a^{ihb172/ihb172} (AB)	standard conditions	Fig. 4 from Yang et al., 2017
whole organism pax2a expression decreased amount, abnormal	foxl2a^{ihb172/ihb172} (AB)	standard conditions	Fig. 5, Fig. 6 from Zhou et al., 2022
ovary senescent, abnormal	foxl2a^{ihb172/ihb172} (AB)	standard conditions	Fig. 4 from Yang et al., 2017
midbrain hindbrain boundary pax2a expression decreased amount, abnormal	foxl2a^{ihb172/ihb172} (AB)	standard conditions	Fig. 6 from Zhou et al., 2022
fourth ventricle decreased size, abnormal	foxl2a^{ihb172/ihb172} (AB)	standard conditions	Fig. 3 from Zhou et al., 2022
roof plate rhombomere region wnt1 expression decreased amount, abnormal	foxl2a^{ihb172/ihb172} (AB)	standard conditions	Fig. 5 from Zhou et al., 2022
ovary tnfrsf1a expression increased amount, abnormal	foxl2a^{ihb172/ihb172} (AB)	standard conditions	Fig. 6 from Yang et al., 2017
testis cyp4t8 expression increased amount, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 9 from Yang et al., 2017
ovary tnfrsf1a expression increased amount, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 9 from Yang et al., 2017
midbrain hindbrain boundary neural keel pax2a expression decreased amount, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 5 from Zhou et al., 2022
whole organism en1b expression decreased amount, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 5, Fig. 6 from Zhou et al., 2022
testis cyp8b1.3 expression increased amount, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 9 from Yang et al., 2017
ovary wt1a expression increased amount, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 9 from Yang et al., 2017
whole organism foxd3 expression increased amount, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 4 from Zhou et al., 2022
ovary amh expression increased amount, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 9 from Yang et al., 2017
testis cyp1c2 expression increased amount, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 9 from Yang et al., 2017
testis cyp11a1.2 expression increased amount, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 9 from Yang et al., 2017
testis sox9a expression increased amount, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 9 from Yang et al., 2017
ovary cyp19a1a expression decreased amount, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 9 from Yang et al., 2017
ovary morphology, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 8 from Yang et al., 2017
testis cyp17a1 expression increased amount, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 9 from Yang et al., 2017
testis tnfrsf1a expression increased amount, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 9 from Yang et al., 2017
ovary senescent, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 8 from Yang et al., 2017
testis cyp2aa12 expression increased amount, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 9 from Yang et al., 2017
roof plate rhombomere region wnt1 expression decreased amount, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 5 from Zhou et al., 2022
ovary cyp8b1.3 expression increased amount, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 9 from Yang et al., 2017
testis dazl expression increased amount, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 9 from Yang et al., 2017
ovary cyp4t8 expression increased amount, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 9 from Yang et al., 2017
midbrain hindbrain boundary pax2a expression decreased amount, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 6 from Zhou et al., 2022
neural crest foxd3 expression increased amount, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 4 from Zhou et al., 2022
whole organism pax2a expression decreased amount, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 5, Fig. 6 from Zhou et al., 2022
ovary spermatogenesis increased occurrence, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 8 from Yang et al., 2017
ovary cyp11a1.2 expression increased amount, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 9 from Yang et al., 2017
testis cyp19a1a expression decreased amount, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 9 from Yang et al., 2017
ovary nr5a1a expression increased amount, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 9 from Yang et al., 2017
midbrain hindbrain boundary wnt1 expression decreased amount, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 6 from Zhou et al., 2022
testis amh expression increased amount, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 9 from Yang et al., 2017
ovary cyp2aa12 expression increased amount, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 9 from Yang et al., 2017
optic stalk pax2a expression decreased amount, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 5 from Zhou et al., 2022
ovary piwil1 expression increased amount, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 9 from Yang et al., 2017
ovary cyp17a1 expression increased amount, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 9 from Yang et al., 2017
ovary nr5a1b expression increased amount, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 9 from Yang et al., 2017
whole organism wnt1 expression decreased amount, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 5, Fig. 6 from Zhou et al., 2022
testis gata4 expression increased amount, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 9 from Yang et al., 2017
testis nr5a1b expression increased amount, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 9 from Yang et al., 2017
oocyte degenerate, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 8 from Yang et al., 2017
ovary gata4 expression increased amount, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 9 from Yang et al., 2017
testis cyp17a2 expression increased amount, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 9 from Yang et al., 2017
ovary sox9a expression increased amount, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 9 from Yang et al., 2017
testis nr5a1a expression increased amount, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 9 from Yang et al., 2017
ovary dmrt1 expression increased amount, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 9 from Yang et al., 2017
testis piwil1 expression increased amount, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 9 from Yang et al., 2017
midbrain hindbrain boundary neural keel wnt1 expression decreased amount, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 5 from Zhou et al., 2022
midbrain hindbrain boundary neural keel en1b expression decreased amount, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 5 from Zhou et al., 2022
testis cyp11a1.1 expression increased amount, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 9 from Yang et al., 2017
fourth ventricle decreased size, exacerbated	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 3 from Zhou et al., 2022
ovary cyp11a1.1 expression increased amount, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 9 from Yang et al., 2017
whole organism ovary male, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 8 from Yang et al., 2017
midbrain hindbrain boundary en1b expression decreased amount, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 6 from Zhou et al., 2022
testis dmrt1 expression increased amount, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 9 from Yang et al., 2017
testis wt1a expression increased amount, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 9 from Yang et al., 2017
ovary cyp1c2 expression increased amount, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 9 from Yang et al., 2017
ovary dazl expression increased amount, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 9 from Yang et al., 2017
ovary cyp17a2 expression increased amount, abnormal	foxl2a^{ihb172/ihb172}; foxl2b^{ihb173/ihb173} (AB)	standard conditions	Fig. 9 from Yang et al., 2017

Citations