TALEN

TALEN1-mt2

ID

ZDB-TALEN-160114-1

Name

TALEN1-mt2

Previous Names

None

Target

mt2 (1)

Target Sequence 1

5' - GTGGATACTCTCTGG - 3'

Target Sequence 2

5' - ACTCTTGGCACATTC - 3'

Disclaimer

Although ZFIN verifies reagent sequence data, we recommend that you conduct independent sequence analysis before ordering any reagent.

Note

None

Genome Resources

None

Target Location

Genome Build: GRCz11Chromosome: 18

Constructs

No data available

Genomic Features

Genomic Feature	Affected Genomic Regions
mu289	mt2
mu290	mt2
mu292	mt2

Expression

Gene expression in Wild Types + TALEN1-mt2

No data available

Phenotype

Phenotype resulting from TALEN1-mt2

No data available

Phenotype of all Fish created by or utilizing TALEN1-mt2

Phenotype	Fish	Conditions	Figures
whole organism decreased size, abnormal	mt2^mu290/mu290	control	Fig. 2 from Schuermann et al., 2015
head necrotic, abnormal	mt2^mu290/mu290	control	Fig. 2 from Schuermann et al., 2015
extension mt2 expression decreased amount, abnormal	mt2^mu290/mu290	control	Fig. 2 from Schuermann et al., 2015
whole organism vegfc expression decreased amount, abnormal	mt2^mu290/mu290	standard conditions	Fig. 4 from Schuermann et al., 2015
primordial hindbrain channel anatomical region mt2 expression absent, abnormal	mt2^mu290/mu290	control	Fig. 2 from Schuermann et al., 2015
primordial hindbrain channel anatomical region mt2 expression absent, abnormal	mt2^mu292/mu292	control	Fig. 2 from Schuermann et al., 2015
whole organism decreased size, abnormal	mt2^mu292/mu292	control	Fig. 2 from Schuermann et al., 2015
head necrotic, abnormal	mt2^mu292/mu292	control	Fig. 2 from Schuermann et al., 2015
extension mt2 expression decreased amount, abnormal	mt2^mu292/mu292	control	Fig. 2 from Schuermann et al., 2015
common cardinal vein endothelial cell decreased amount, abnormal	mt2^mu289/mu289; y1Tg	control	Fig. S4 from Schuermann et al., 2015
common cardinal vein angiogenesis decreased occurrence, abnormal	mt2^mu289/mu289; y1Tg	control	Fig. S4 from Schuermann et al., 2015
primordial hindbrain channel cell migration involved in sprouting angiogenesis decreased occurrence, abnormal	mt2^mu290/mu290; y1Tg	control	Fig. 2 from Schuermann et al., 2015
intersegmental vessel malformed, abnormal	mt2^mu290/mu290; y1Tg	control	Fig. S4 from Schuermann et al., 2015
common cardinal vein endothelial cell decreased amount, abnormal	mt2^mu290/mu290; y1Tg	control	Fig. S4 from Schuermann et al., 2015
intersegmental vessel angiogenesis arrested, abnormal	mt2^mu290/mu290; y1Tg	control	Fig. S4 from Schuermann et al., 2015
primordial hindbrain channel blood vessel development decreased occurrence, abnormal	mt2^mu290/mu290; y1Tg	control	Fig. 2 from Schuermann et al., 2015
common cardinal vein angiogenesis decreased occurrence, abnormal	mt2^mu290/mu290; y1Tg	control	Fig. S4 from Schuermann et al., 2015
primordial hindbrain channel cell migration involved in sprouting angiogenesis decreased occurrence, abnormal	mt2^mu292/mu292; s843Tg	control	Fig. 2 from Schuermann et al., 2015
intersegmental vessel angiogenesis arrested, abnormal	mt2^mu292/mu292; s843Tg	control	Fig. S4 from Schuermann et al., 2015
intersegmental vessel malformed, abnormal	mt2^mu292/mu292; s843Tg	control	Fig. S4 from Schuermann et al., 2015
common cardinal vein endothelial cell decreased amount, abnormal	mt2^mu292/mu292; s843Tg	control	Fig. S4 from Schuermann et al., 2015
primordial hindbrain channel blood vessel development decreased occurrence, abnormal	mt2^mu292/mu292; s843Tg	control	Fig. 2 from Schuermann et al., 2015
common cardinal vein angiogenesis decreased occurrence, abnormal	mt2^mu292/mu292; s843Tg	control	Fig. S4 from Schuermann et al., 2015

Citations

Include unpublished citations

Schuermann, A., Helker, C.S., Herzog, W. (2015) Metallothionein 2 regulates endothelial cell migration through transcriptional regulation of vegfc expression. Angiogenesis. 18(4):463-75

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