PUBLICATION

Zebrafish genetic map with 2000 microsatellite markers

Authors
Shimoda, N., Knapik, E.W., Ziniti, J., Sim, C., Yamada, E., Kaplan, S., Jackson, D., de Sauvage, F., Jacob, H., and Fishman, M.C.
ID
ZDB-PUB-990628-13
Date
1999
Source
Genomics   58(3): 219-232 (Journal)
Registered Authors
de Sauvage, Frederic J., Fishman, Mark C., Jackson, Don, Knapik, Ela W., Shimoda, Nobuyoshi, Sim, Chäng, Ziniti, John
Keywords
zebrafish; linkage map; microsatellite repeat; polymorphism; microsatellite expansion
MeSH Terms
  • Female
  • Mutation
  • Physical Chromosome Mapping
  • Animals
  • Cloning, Molecular
  • Zebrafish/genetics*
  • Male
  • Gene Library
  • Microsatellite Repeats/genetics*
  • Genetic Linkage
  • Genome
(all 11)
PubMed
10373319 Full text @ Genomics
Abstract
The zebrafish is the first vertebrate organism used for large-scale genetic screens seeking genes critical to development. These screens have been quite successful, with more than 1800 recessive mutations discovered that speak to morphogenesis of the vertebrate embryo. The cloning of the mutant genes depends on a dense genetic map. The 2000 markers we present here, using microsatellite (CA) repeats, provides 1.2-cM average resolution. One centimorgan in zebrafish is about 0.74 megabase, so, for many mutations, these markers are close enough to begin positional cloning by YAC walks.
Genes / Markers
Figures
No images available
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
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Citation
Shimoda, N., Knapik, E.W., Ziniti, J., Sim, C., Yamada, E., Kaplan, S., Jackson, D., de Sauvage, F., Jacob, H., and Fishman, M.C. (1999) Zebrafish genetic map with 2000 microsatellite markers. Genomics. 58(3):219-232.