PUBLICATION

Zebrafish genetic map with 2000 microsatellite markers

Authors
Shimoda, N., Knapik, E.W., Ziniti, J., Sim, C., Yamada, E., Kaplan, S., Jackson, D., de Sauvage, F., Jacob, H., and Fishman, M.C.
ID
ZDB-PUB-990628-13
Date
1999
Source
Genomics   58(3): 219-232 (Journal)
Registered Authors
de Sauvage, Frederic J., Fishman, Mark C., Jackson, Don, Knapik, Ela W., Shimoda, Nobuyoshi, Sim, Chäng, Ziniti, John
Keywords
zebrafish; linkage map; microsatellite repeat; polymorphism; microsatellite expansion
MeSH Terms
  • Animals
  • Genetic Linkage
  • Microsatellite Repeats/genetics*
  • Zebrafish/genetics*
  • Gene Library
  • Genome
  • Female
  • Mutation
  • Physical Chromosome Mapping
  • Cloning, Molecular
  • Male
(all 11)
PubMed
10373319 Full text @ Genomics
Abstract
The zebrafish is the first vertebrate organism used for large-scale genetic screens seeking genes critical to development. These screens have been quite successful, with more than 1800 recessive mutations discovered that speak to morphogenesis of the vertebrate embryo. The cloning of the mutant genes depends on a dense genetic map. The 2000 markers we present here, using microsatellite (CA) repeats, provides 1.2-cM average resolution. One centimorgan in zebrafish is about 0.74 megabase, so, for many mutations, these markers are close enough to begin positional cloning by YAC walks.
Genes / Markers
Figures
No images available
Expression
Phenotype
No data available
Mutations / Transgenics
Allele Construct Type Affected Genomic Region
rw16
    		Point Mutation
    1 - 1 of 1
    Show
    Human Disease / Model
    No data available
    Sequence Targeting Reagents
    No data available
    Fish
    Fish
    scribrw16/rw16
    1 - 1 of 1
    Show
    Antibodies
    No data available
    Orthology
    No data available
    Engineered Foreign Genes
    No data available
    Mapping
    Entity Type Entity Symbol Location
    Featurerw16Chr: 7 Details
    SSLPz11545Chr: 7 Details
    SSLPz62080Chr: 7 Details
    1 - 3 of 3
    Show
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    Citation
    Shimoda, N., Knapik, E.W., Ziniti, J., Sim, C., Yamada, E., Kaplan, S., Jackson, D., de Sauvage, F., Jacob, H., and Fishman, M.C. (1999) Zebrafish genetic map with 2000 microsatellite markers. Genomics. 58(3):219-232.