ZFIN ID: ZDB-PUB-990607-17
Mueggelone, a novel inhibitor of fish development from the fresh water cyanobacterium Aphanizomenon flos-aquae
Papendorf, O., König, G.M., Wright, A.D., Chorus, I., and Oberemm, A.
Date: 1997
Source: Journal of natural products   60(12): 1298-1300 (Journal)
Registered Authors: Oberemm, Axel, Wright, Christopher V.E.
Keywords: none
MeSH Terms:
  • Animals
  • Cyanobacteria/chemistry
  • Cyanobacteria/metabolism*
  • Fishes/growth & development*
  • Growth Inhibitors/isolation & purification*
  • Growth Inhibitors/pharmacology
  • Lactones/isolation & purification*
  • Lactones/pharmacology
  • Larva/drug effects
  • Larva/growth & development
PubMed: 9428164 Full text @ J. Nat. Prod.
A novel C18 lipid, containing a 10-membered lactone, mueggelone (1), was isolated from a field-collected sample of Aphanizomenon flos-aquae, together with the known compound lupenyl acetate (3). Both structures were secured using extensive spectroscopic analysis (1D and 2D NMR, MS, IR). Biological activity assessment of both compounds indicated them to have significant inhibitory effects on fish embryo larval development.