ZFIN ID: ZDB-PUB-990210-16
The generation and interpretation of positional information within the vertebrate myotome
Currie P.D. and Ingham P.W.
Date: 1998
Source: Mechanisms of Development   73: 3-21 (Review)
Registered Authors: Currie, Peter D., Ingham, Philip
Keywords: none
MeSH Terms:
  • Animals
  • Cell Differentiation/genetics
  • Cell Differentiation/physiology
  • Drosophila Proteins*
  • Embryonic Induction/genetics
  • Gene Expression Regulation, Developmental/genetics
  • Gene Expression Regulation, Developmental/physiology
  • Hedgehog Proteins
  • Insect Proteins/genetics
  • Mesoderm/cytology
  • Mesoderm/physiology
  • Muscle, Skeletal/cytology
  • Muscle, Skeletal/embryology*
  • Protein Processing, Post-Translational/genetics
  • Transcription Factors/physiology
  • Vertebrates/embryology*
PubMed: 9545513 Full text @ Mech. Dev.
How somitic cells become restricted to the muscle fate has been investigated on a number of levels. Classical embryological manipulations have attempted to define the source of inductive signals that control the formation of the myotome. Recently, these studies have converged with others dissecting the role of secreted proteins in embryonic patterning to demonstrate a role for specific peptides in inducing individual cell types of the myotome. Collectively, these investigations have implicated the products of the Wnt, Hedgehog (Hh) and Bone morphogenetic protein (Bmp) gene families as key myogenic regulators; simultaneously controlling both the initiation of myogenesis and the fate of individual myoblasts.