PUBLICATION
The generation and interpretation of positional information within the vertebrate myotome
- Authors
- Currie P.D. and Ingham P.W.
- ID
- ZDB-PUB-990210-16
- Date
- 1998
- Source
- Mechanisms of Development 73: 3-21 (Review)
- Registered Authors
- Currie, Peter D., Ingham, Philip
- Keywords
- none
- MeSH Terms
-
- Embryonic Induction/genetics
- Insect Proteins/genetics
- Gene Expression Regulation, Developmental/genetics
- Gene Expression Regulation, Developmental/physiology
- Vertebrates/embryology*
- Animals
- Transcription Factors/physiology
- Hedgehog Proteins
- Muscle, Skeletal/cytology
- Muscle, Skeletal/embryology*
- Drosophila Proteins*
- Mesoderm/cytology
- Mesoderm/physiology
- Protein Processing, Post-Translational/genetics
- Cell Differentiation/genetics
- Cell Differentiation/physiology
- PubMed
- 9545513 Full text @ Mech. Dev.
Citation
Currie P.D. and Ingham P.W. (1998) The generation and interpretation of positional information within the vertebrate myotome. Mechanisms of Development. 73:3-21.
Abstract
How somitic cells become restricted to the muscle fate has been investigated on a number of levels. Classical embryological manipulations have attempted to define the source of inductive signals that control the formation of the myotome. Recently, these studies have converged with others dissecting the role of secreted proteins in embryonic patterning to demonstrate a role for specific peptides in inducing individual cell types of the myotome. Collectively, these investigations have implicated the products of the Wnt, Hedgehog (Hh) and Bone morphogenetic protein (Bmp) gene families as key myogenic regulators; simultaneously controlling both the initiation of myogenesis and the fate of individual myoblasts.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping