| ZFIN ID: ZDB-PUB-980105-1 |
Cleavage of the BMP-4 antagonist chordin by zebrafish tolloid
Blader, P., Rastegar, S., Fischer, N., and Strähle, U.
| Date: | 1997 |
|---|---|
| Source: | Science (New York, N.Y.) 278(5345): 1937-1940 (Journal) |
| Registered Authors: | Blader, Patrick, Fischer, Nadine, Rastegar, Sepand, Strähle, Uwe |
| Keywords: | none |
| MeSH Terms: |
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| PubMed: | 9395394 Full text @ Science |
Citation
Blader, P., Rastegar, S., Fischer, N., and Strähle, U. (1997) Cleavage of the BMP-4 antagonist chordin by zebrafish tolloid. Science (New York, N.Y.). 278(5345):1937-1940.
ABSTRACT
Dorsoventral patterning of vertebrate and Drosophila embryos requires bone morphogenetic proteins (BMPs) and antagonists of BMP activity. The Drosophila gene tolloid encodes a metalloprotease similar to BMP-1 that interacts genetically with decapentaplegic, the Drosophila homolog of vertebrate BMP-2/4. Zebrafish embryos overexpressing a zebrafish homolog of tolloid were shown to resemble loss-of-function mutations in chordino, the zebrafish homolog of the Xenopus BMP-4 antagonist Chordin. Furthermore, Chordin was degraded by COS cells expressing Tolloid. These data suggest that Tolloid antagonizes Chordin activity by proteolytically cleaving Chordin. A conserved function for zebrafish and Drosophila Tolloid during embryogenesis is proposed.
ADDITIONAL INFORMATION
- Genes / Markers (5)
- Fish (1)