PUBLICATION
Combinatorial and chemotopic odorant coding in the zebrafish olfactory bulb visualized by optical imaging
- Authors
- Friedrich, R.W. and Korsching, S.I.
- ID
- ZDB-PUB-970724-4
- Date
- 1997
- Source
- Neuron 18(5): 737-752 (Journal)
- Registered Authors
- Friedrich, Rainer, Korsching, Sigrun
- Keywords
- none
- MeSH Terms
-
- Image Processing, Computer-Assisted
- Olfactory Nerve/cytology
- Olfactory Nerve/physiology
- Olfactory Bulb/cytology
- Olfactory Bulb/physiology*
- Amino Acids/pharmacology
- Denervation
- Zebrafish/physiology*
- Receptors, Odorant/drug effects
- Receptors, Odorant/physiology*
- Animals
- Olfactory Receptor Neurons/chemistry
- Olfactory Receptor Neurons/physiology
- Dose-Response Relationship, Drug
- Nerve Regeneration/physiology
- Smell/physiology*
- Multivariate Analysis
- Presynaptic Terminals/chemistry
- Presynaptic Terminals/physiology
- Calcium/metabolism
- PubMed
- 9182799 Full text @ Neuron
Citation
Friedrich, R.W. and Korsching, S.I. (1997) Combinatorial and chemotopic odorant coding in the zebrafish olfactory bulb visualized by optical imaging. Neuron. 18(5):737-752.
Abstract
Odors are thought to be represented by a distributed code across the glomerular modules in the olfactory bulb (OB). Here, we optically imaged presynaptic activity in glomerular modules of the zebrafish OB induced by a class of natural odorants (amino acids [AAs]) after labeling of primary afferents with a calcium-sensitive dye. AAs induce complex combinatorial patterns of active glomerular modules that are unique for different stimuli and concentrations. Quantitative analysis shows that defined molecular features of stimuli are correlated with activity in spatially confined groups of glomerular modules. These results provide direct evidence that identity and concentration of odorants are encoded by glomerular activity patterns and reveal a coarse chemotopic organization of the array of glomerular modules.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping