PUBLICATION

Zebrafish Radar: a new member of the TGF-ß superfamily defines dorsal regions of the neural plate and the embryonic retina

Authors
Rissi, M., Wittbrodt, J., Delot, E., Naegeli, M., and Rosa, F.M.
ID
ZDB-PUB-961014-939
Date
1995
Source
Mechanisms of Development   49(3): 223-34 (Journal)
Registered Authors
Delot, Emmanuele, Rosa, Frederic, Wittbrodt, Jochen
Keywords
none
MeSH Terms
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cloning, Molecular
  • Conserved Sequence
  • Molecular Sequence Data
  • Neural Crest/embryology*
  • Retina/embryology*
  • Sequence Alignment
  • Transforming Growth Factor beta/genetics*
  • Transforming Growth Factor beta/isolation & purification
  • Zebrafish/embryology*
PubMed
7734395 Full text @ Mech. Dev.
Abstract
Proper development of metazoan embryos requires cell to cell communications. In many instances, these communications involve diffusible molecules, particularly members of the Transforming Growth Factor beta superfamily. In an effort to identify new members of this superfamily involved in the control of early zebrafish embryogenesis, we have isolated a gene, Radar, which appears to be conserved throughout vertebrate evolution and defines a new subfamily within the superfamily. Its pattern of expression suggests that Radar plays a role in the dorso- ventral polarity of the neural plate, blood islands formation, blood cells differentiation, the establishment of retinal dorso-ventral polarity and/or proper axonal retinotectal projections. Radar expression in ntl homozygous mutants indicates that notochord and hypochord development are intimately linked.
Genes / Markers
Figures
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Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping