PUBLICATION
Role of notochord in specification of cardiac left-right orientation in zebrafish and Xenopus
- Authors
- Danos, M.C. and Yost, H.J.
- ID
- ZDB-PUB-961014-198
- Date
- 1996
- Source
- Developmental Biology 177: 96-103 (Journal)
- Registered Authors
- Danos, Maria, Yost, H. Joseph
- Keywords
- none
- MeSH Terms
-
- Embryonic and Fetal Development/physiology
- Transcription, Genetic
- T-Box Domain Proteins*
- DNA-Binding Proteins/genetics
- Transcription Factors/genetics
- PubMed
- 8660880 Full text @ Dev. Biol.
Abstract
The left-right body axis is coordinately aligned with the orthogonal dorsoventral and anterioposterior body axes. The developmental mechanisms that regulate axis coordination are unknown. Here it is shown that the cardiac left-right orientation in zebrafish (Danio rerio) is randomized in notochord-defective no tail and floating head mutants. no tail (Brachyury) and floating head (Xnot) encode putative transcription factors that are expressed in the organizer and notochord, structures which regulate dorsoventral and anterioposterior development in vertebrate embryos. Results from dorsal tissue extirpation and cardiac primordia explantation indicate that cardiac left-right orientation is dependent on dorsoanterior structures including the notochord and is specified during neural fold stages in Xenopus laevis. Thus, the notochord coordinates the development of all three body axes in the vertebrate body plan.
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