PUBLICATION
The role of Nrf2 in thyroid maturation and hormone synthesis in vertebrate models
- Authors
- Gillotay, P., Bangru, S., Dassy, B., Haerlingen, B., Shankar, M.P., Fonseca, B.F., Ziros, P.G., Singh, S.P., Sykiotis, G.P., Romitti, M., Costagliola, S.
- ID
- ZDB-PUB-260508-4
- Date
- 2026
- Source
- Life science alliance 9: (Journal)
- Registered Authors
- Bangru, Sushant, Costagliola, Sabine, Gillotay, Pierre, Singh, Sumeet Pal
- Keywords
- none
- MeSH Terms
- none
- PubMed
- 42097882 Full text @ Life Sci Alliance
Citation
Gillotay, P., Bangru, S., Dassy, B., Haerlingen, B., Shankar, M.P., Fonseca, B.F., Ziros, P.G., Singh, S.P., Sykiotis, G.P., Romitti, M., Costagliola, S. (2026) The role of Nrf2 in thyroid maturation and hormone synthesis in vertebrate models. Life science alliance. 9:.
Abstract
In vertebrates, the thyroid gland synthesizes hormones that act on almost all tissues and are essential for normal growth and metabolism. Thyroid hormone production relies on iodination of thyroglobulin and requires H2O2, which contributes to a relatively high basal oxidative stress in the thyroid that must be tightly controlled to prevent cellular damage. The thyroid has efficient antioxidant and detoxifying enzymes that help it resist H2O2-induced oxidative stress maintaining the homeostasis necessary for hormone synthesis. By regulating the expression of genes involved in cellular detoxification, NRF2 acts as a master regulator of the cellular defense against oxidative stress. Using zebrafish embryos and mouse ESC-derived thyroid organoids, we generated nrf2a/Nrf2 loss-of-function and identified a common dyshormonogenesis phenotype. Although in zebrafish, the driving mechanisms are possibly related to thyroglobulin iodination defects, in thyroid organoids, it is likely due to a reduction in Tg production, consequently affecting folliculogenesis and thyroid hormone production.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping