ZFIN ID: ZDB-PERS-090112-4
Singh, Sumeet Pal
Email: sumeet.pal.singh@ulb.be
URL: http://sumeetpalsingh.github.io/
Affiliation: Sumeet Singh Lab
Address: IRIBHM ULB Building C, Floor 6, Room C6.126 808 route de Lennik 1070 Brussels
Country: Belgium
Phone: +32-2555-6180
Fax:
ORCID ID: 0000-0002-5154-3318


BIOGRAPHY AND RESEARCH INTERESTS
Sumeet Pal Singh, PhD is an alumni of Indian Institute of Technology (IIT), Kanpur. He graduated in 2004 with a B.Tech. degree in Biological Sciences and Bioengineering. Directly after bachelor’s degree, he joined the PhD program at Duke University, USA where he performed his doctorate under the supervision of Dr. Kenneth Poss. For his thesis, Sumeet worked on the cellular basis of bone regeneration in the zebrafish fin amputation model.

For post-doctoral work, Sumeet started work on planarian model system, a fascinating organism with extraordinary regenerative capacity, in the lab of Dr. Jochen Rink at the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), Germany.

For his second post-doc, he returned to zebrafish research in the lab of Dr. Nikolay Ninov at Center for Regenerative Therapies Dresden (CRTD), Germany. Focussing on the pancreatic beta-cells, Sumeet uncovered latent heterogeneity in the beta-cell population. For this, he developed several transgenic reagents to interrogate the proliferative and functional differences among individual cells. He was awarded an EFSD/Lilly Young Investigator Fellowship for his efforts.

In 2019, Sumeet was awarded the Mandat d’impulsion scientifique - mobilité Ulysse (MISU) by Le Fonds de la Recherche Scientifique (FNRS) to start his group at IRIBHM, part of ULB in Brussels, Belgium.


PUBLICATIONS
Pronobis, M.I., Zheng, S., Singh, S.P., Goldman, J.A., Poss, K.D. (2021) In vivo proximity labeling identifies cardiomyocyte protein networks during zebrafish heart regeneration. eLIFE. 10:
Eski, S.E., Dubois, C., Singh, S.P. (2020) Nuclei Isolation from Whole Tissue using a Detergent and Enzyme-Free Method. Journal of visualized experiments : JoVE. (160):
Singh, S.P., Ninov, N. (2020) Multicolor Labeling and Tracing of Pancreatic Beta-Cell Proliferation in Zebrafish. Methods in molecular biology (Clifton, N.J.). 2128:159-179
Salem, V., Silva, L.D., Suba, K., Georgiadou, E., Neda Mousavy Gharavy, S., Akhtar, N., Martin-Alonso, A., Gaboriau, D.C.A., Rothery, S.M., Stylianides, T., Carrat, G., Pullen, T.J., Singh, S.P., Hodson, D.J., Leclerc, I., Shapiro, A.M.J., Marchetti, P., Briant, L.J.B., Distaso, W., Ninov, N., Rutter, G.A. (2019) Leader β-cells coordinate Ca2+ dynamics across pancreatic islets in vivo. Nature metabolism. 1:615-629
Cox, B.D., De Simone, A., Tornini, V.A., Singh, S.P., Di Talia, S., Poss, K.D. (2018) In Toto Imaging of Dynamic Osteoblast Behaviors in Regenerating Skeletal Bone. Current biology : CB. 28(24):3937-3947.e4
Singh, S.P., Janjuha, S., Chaudhuri, S., Reinhardt, S., Kränkel, A., Dietz, S., Eugster, A., Bilgin, H., Korkmaz, S., Zararsız, G., Ninov, N., Reid, J.E. (2018) Machine learning based classification of cells into chronological stages using single-cell transcriptomics. Scientific Reports. 8:17156
Janjuha, S., Pal Singh, S., Ninov, N. (2018) Analysis of Beta-cell Function Using Single-cell Resolution Calcium Imaging in Zebrafish Islets. Journal of visualized experiments : JoVE. (137)
Janjuha, S., Singh, S.P., Tsakmaki, A., Mousavy-Gharavy, N., Murawala, P., Konantz, J., Birke, S., Hodson, D.J., Rutter, G., Bewick, G., Ninov, N.N. (2018) Age-related islet inflammation marks the proliferative decline of pancreatic beta-cells in zebrafish. eLIFE. 7
Singh, S.P., Janjuha, S., Hartmann, T., Kayisoglu, Ö., Konantz, J., Birke, S., Murawala, P., Alfar, E.A., Murata, K., Eugster, A., Tsuji, N., Morrissey, E.R., Brand, M., Ninov, N. (2017) Different developmental histories of beta-cells generate functional and proliferative heterogeneity during islet growth. Nature communications. 8:664
Singh, S.P., Holdway, J.E., and Poss, K.D. (2012) Regeneration of amputated zebrafish fin rays from de novo osteoblasts. Developmental Cell. 22(4):879-886
Wang, J., Panáková, D., Kikuchi, K., Holdway, J.E., Gemberling, M., Burris, J.S., Singh, S.P., Dickson, A.L., Lin, Y.F., Sabeh, M.K., Werdich, A.A., Yelon, D., MacRae, C.A., and Poss, K.D. (2011) The regenerative capacity of zebrafish reverses cardiac failure caused by genetic cardiomyocyte depletion. Development (Cambridge, England). 138(16):3421-30

NON-ZEBRAFISH PUBLICATIONS