PUBLICATION
IL-22 from enteroendocrine cells promotes early-life gut motility in zebrafish through the microbiota
- Authors
- Rabahi, S., Maurin, L., Marachlian, E., Guendel, F., Mikdache, A., Quintero-Castillo, K., Di Donato, V., Riou-Ramon, J., Kurup, A.J., Salloum, Y., Gros, G., Diabangouaya, P., Garcia-Baudino, C., Medina-Yáñez, I., Hersen, P., Banderas, A., Levraud, J.P., Lutfalla, G., Del Bene, F., Feijoo, C.G., Eberl, G., Sumbre, G., Boekhorst, J., Brugman, S., Hernandez, P.P.
- ID
- ZDB-PUB-260422-14
- Date
- 2026
- Source
- Science (New York, N.Y.) 392: 697669-76 (Journal)
- Registered Authors
- Del Bene, Filippo, Diabangouaya, Patricia, Feijoo, Carmen G., Hernandez Cerda, Pedro, Kurup, Akshai Janardhana, Levraud, Jean-Pierre, Lutfalla, Georges, Rabahi, Soraya, Sumbre, Germán
- Keywords
- none
- MeSH Terms
- none
- PubMed
- 42012839 Full text @ Science
Citation
Rabahi, S., Maurin, L., Marachlian, E., Guendel, F., Mikdache, A., Quintero-Castillo, K., Di Donato, V., Riou-Ramon, J., Kurup, A.J., Salloum, Y., Gros, G., Diabangouaya, P., Garcia-Baudino, C., Medina-Yáñez, I., Hersen, P., Banderas, A., Levraud, J.P., Lutfalla, G., Del Bene, F., Feijoo, C.G., Eberl, G., Sumbre, G., Boekhorst, J., Brugman, S., Hernandez, P.P. (2026) IL-22 from enteroendocrine cells promotes early-life gut motility in zebrafish through the microbiota. Science (New York, N.Y.). 392:697669-76.
Abstract
The gut microbiota, immune system, and enteric nervous system interact to regulate adult gut physiology. However, the mechanisms establishing gut physiology during development remain unknown. We report that in developing zebrafish, enteroendocrine cells produced interleukin-22 (IL-22) in response to microbial signals before lymphocytes populated the gut. In larvae, IL-22 shaped the gut microbiota, increasing Lactobacillaceae abundance and ghrelin expression to promote gut motility. Impaired motility and ghrelin expression were restored in il22-/- zebrafish by transfer of microbiota from wild-type zebrafish or by introducing only Lactobacillus plantarum. IL-22-deficient mice also had impaired gut motility and reduced ghrelin expression in early life, indicating a conserved function. Thus, before immune system maturation, enteroendocrine cells regulate early-life gut function by controlling the microbiota through IL-22.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping