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Lutfalla, Georges
Affiliation: Lutfalla Lab
Address: DIMNP CNRS UMR5235, cc107 Université Montpellier 2 Place Eugène Bataillon 34095 Montpellier Cedex 05 France
Country: France
Phone: 33-467-14-92-15
Fax: 33-467-14-92-01

Evolution of the helical cytokines and their receptors during chordate and vertebrate radiation.

Immunology and development.

Sipka, T., Peroceschi, R., Hassan-Abdi, R., Groß, M., Ellett, F., Begon-Pescia, C., Gonzalez, C., Lutfalla, G., Nguyen-Chi, M. (2021) Damage-Induced Calcium Signaling and Reactive Oxygen Species Mediate Macrophage Activation in Zebrafish. Frontiers in immunology. 12:636585
Nguyen-Chi, M., Luz-Crawford, P., Balas, L., Sipka, T., Contreras-López, R., Barthelaix, A., Lutfalla, G., Durand, T., Jorgensen, C., Djouad, F. (2020) Pro-resolving mediator Protectin D1 promotes epimorphic regeneration by controlling immune cell function in vertebrates. British journal of pharmacology. 177(17):4055-4073
Maarifi, G., Smith, N., Maillet, S., Moncorgé, O., Chamontin, C., Edouard, J., Sohm, F., Blanchet, F.P., Herbeuval, J.P., Lutfalla, G., Levraud, J.P., Arhel, N.J., Nisole, S. (2019) TRIM8 is required for virus-induced IFN response in human plasmacytoid dendritic cells. Science advances. 5:eaax3511
Phan, Q.T., Sipka, T., Gonzalez, C., Levraud, J.P., Lutfalla, G., Nguyen-Chi, M. (2018) Neutrophils use superoxide to control bacterial infection at a distance. PLoS pathogens. 14:e1007157
Nguyen-Chi, M., Laplace-Builhé, B., Travnickova, J., Luz-Crawford, P., Tejedor, G., Lutfalla, G., Kissa, K., Jorgensen, C., Djouad, F. (2018) Correction to: TNF signaling and macrophages govern fin regeneration in zebrafish larvae. Cell Death & Disease. 9:709
Morris, E.A., Bodin, S., Delaval, B., Comunale, F., Georget, V., Costa, M.L., Lutfalla, G., Gauthier-Rouvière, C. (2017) Flotillins control zebrafish epiboly through their role in cadherin-mediated cell-cell adhesion. Biology of the cell. 109(5):210-221
Bernut, A., Nguyen-Chi, M., Halloum, I., Herrmann, J.L., Lutfalla, G., Kremer, L. (2016) Mycobacterium abscessus-Induced Granuloma Formation Is Strictly Dependent on TNF Signaling and Neutrophil Trafficking. PLoS pathogens. 12:e1005986
Halloum, I., Carrère-Kremer, S., Blaise, M., Viljoen, A., Bernut, A., Le Moigne, V., Vilchèze, C., Guérardel, Y., Lutfalla, G., Herrmann, J.L., Jacobs, W.R., Kremer, L. (2016) Deletion of a dehydratase important for intracellular growth and cording renders rough Mycobacterium abscessus avirulent. Proceedings of the National Academy of Sciences of the United States of America. 113(29):E4228-37
Faure, E., Savy, T., Rizzi, B., Melani, C., Stašová, O., Fabrèges, D., Špir, R., Hammons, M., Čúnderlík, R., Recher, G., Lombardot, B., Duloquin, L., Colin, I., Kollár, J., Desnoulez, S., Affaticati, P., Maury, B., Boyreau, A., Nief, J.Y., Calvat, P., Vernier, P., Frain, M., Lutfalla, G., Kergosien, Y., Suret, P., Remešíková, M., Doursat, R., Sarti, A., Mikula, K., Peyriéras, N., Bourgine, P. (2016) A workflow to process 3D+time microscopy images of developing organisms and reconstruct their cell lineage. Nature communications. 7:8674
Piazzon, M.C., Lutfalla, G., Forlenza, M. (2016) IL10, A Tale of an Evolutionarily Conserved Cytokine across Vertebrates. Critical reviews in immunology. 36:99-129
Bernut, A., Dupont, C., Sahuquet, A., Herrmann, J.L., Lutfalla, G., Kremer, L. (2015) Deciphering and Imaging Pathogenesis and Cording of Mycobacterium abscessus in Zebrafish Embryos. Journal of visualized experiments : JoVE. (103):e53130
Nguyen Chi, M., Laplace-Builhe, B., Travnickova, J., Luz-Crawford, P., Tejedor, G., Phan, Q.T., Duroux-Richard, I., Levraud, J.P., Kissa, K., Lutfalla, G., Jorgensen, C., Djouad, F. (2015) Identification of polarized macrophage subsets in zebrafish. eLIFE. 4:e07288
Bernut, A., Lutfalla, G., Kremer, L. (2015) [Looking through zebrafish to study host-pathogen interactions]. Medecine sciences : M/S. 31:638-46
Madgwick, A., Fort, P., Hanson, P.S., Thibault, P., Gaudreau, M.C., Lutfalla, G., Möröy, T., Abou Elela, S., Chaudhry, B., Elliott, D.J., Morris, C.M., Venables, J.P. (2015) Neural Differentiation Modulates the Vertebrate Brain Specific Splicing Program. PLoS One. 10:e0125998
Belon, C., Gannoun-Zaki, L., Lutfalla, G., Kremer, L., Blanc-Potard, A. (2014) Mycobacterium marinum MgtC Plays a Role in Phagocytosis but is Dispensable for Intracellular Multiplication. PLoS One. 9:e116052
Nguyen-Chi, M., Phan, Q.T., Gonzalez, C., Dubremetz, J.F., Levraud, J.P., Lutfalla, G. (2014) Transient infection of the zebrafish notochord with E. coli induces chronic inflammation. Disease models & mechanisms. 7:871-882
Bernut, A., Le Moigne, V., Lesne, T., Lutfalla, G., Herrmann, J.L., Kremer, L. (2014) In vivo assessment of drug efficacy against Mycobacterium abscessus using the embryonic zebrafish test system. Antimicrobial Agents and Chemotherapy. 58(7):4054-4063
Bernut, A., Herrmann, J.L., Lutfalla, G., Kremer, L. (2014) [Mycobacterial cording: a new mechanism of immune evasion?]. Medecine sciences : M/S. 30:499-502
Bernut, A., Herrmann, J.L., Kissa, K., Dubremetz, J.F., Gaillard, J.L., Lutfalla, G., Kremer, L. (2014) Mycobacterium abscessus cording prevents phagocytosis and promotes abscess formation. Proceedings of the National Academy of Sciences of the United States of America. 111:E943-52
Fontenille, L., Rouquier, S., Lutfalla, G., Giorgi, D. (2014) Microtubule-associated protein 9 (Map9/Asap) is required for the early steps of zebrafish development. Cell cycle (Georgetown, Tex.). 13(7):1101-14
Palha, N., Guivel-Benhassine, F., Briolat, V., Lutfalla, G., Sourisseau, M., Ellett, F., Wang, C.H., Lieschke, G.J., Herbomel, P., Schwartz, O., and Levraud, J.P. (2013) Real-time whole-body visualization of chikungunya virus infection and host interferon response in zebrafish. PLoS pathogens. 9(9):e1003619
Hamming, O.J., Lutfalla, G., Levraud, J.P., and Hartmann, R. (2011) Crystal structure of zebrafish Interferons 1 and 2 reveals a conservation of type I Interferon structure in vertebrates. Journal of virology. 85(16):8181-7
Alibaud, L., Rombouts, Y., Trivelli, X., Burguière, A., Cirillo, S.L., Cirillo, J.D., Dubremetz, J.F., Guérardel, Y., Lutfalla, G., and Kremer, L. (2011) A Mycobacterium marinum TesA mutant defective for major cell wall associated lipids is highly attenuated in Dictyostelium discoideum and zebrafish embryos. Molecular Microbiology. 80(4):919-934
Aggad, D., Stein, C., Sieger, D., Mazel, M., Boudinot, P., Herbomel, P., Levraud, J.P., Lutfalla, G., and Leptin, M. (2010) In Vivo Analysis of Ifn-γ1 and Ifn-γ2 Signaling in Zebrafish. Journal of immunology (Baltimore, Md. : 1950). 185(11):6774-6782
Gamba, L., Cubedo, N., Lutfalla, G., Ghysen, A., and Dambly-Chaudiere, C. (2010) Lef1 controls patterning and proliferation in the posterior lateral line system of zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 239(12):3163-3171
Gamba, L., Cubedo, N., Ghysen, A., Lutfalla, G., and Dambly-Chaudière, C. (2010) Estrogen receptor ESR1 controls cell migration by repressing chemokine receptor CXCR4 in the zebrafish posterior lateral line system. Proceedings of the National Academy of Sciences of the United States of America. 107(14):6358-6363
Aggad, D., Mazel, M., Boudinot, P., Mogensen, K.E., Hamming, O.J., Hartmann, R., Kotenko, S., Herbomel, P., Lutfalla, G., and Levraud, J.P. (2009) The two groups of zebrafish virus-induced interferons signal via distinct receptors with specific and shared chains. Journal of immunology (Baltimore, Md. : 1950). 183(6):3924-3931
Levraud, J.P., Colucci-Guyon, E., Redd, M.J., Lutfalla, G., and Herbomel, P. (2008) In Vivo Analysis of Zebrafish Innate Immunity. Methods in molecular biology (Clifton, N.J.). 415:337-363
Levraud, J.P., Boudinot, P., Colin, I., Benmansour, A., Peyriéras, N., Herbomel, P., and Lutfalla, G. (2007) Identification of the Zebrafish IFN Receptor: Implications for the Origin of the Vertebrate IFN System. Journal of immunology (Baltimore, Md. : 1950). 178(7):4385-4394
Lutfalla, G., Roest Crollius, H., Stange-Thomann, N., Jaillon, O., Mogensen, K., and Monneron, D. (2003) Comparative genomic analysis reveals independent expansion of a lineage-specific gene family in vertebrates: The class II cytokine receptors and their ligands in mammals and fish. BMC Genomics. 4(1):29

mouse cells. Cloning and expression of its cDNA. Cell 60, 225-243.

Legouis R., Hardelin J.P., Levilliers J., Claverie J.M., Compain S., Wunderle V., Milasseau P., Le Paslier D., Cohen D., Caterina D., Bougueleret L., Delemare-Van de Waal, H., Lutfalla G., Weissenbach J. and Petit C. (1991) The candidate gene for the X-linked Kallmann syndrome encodes a protein related to adhesion molecules. Cell, 67, 423-435.

del Castillo, I., Cohen-Salmon, M., Blanchard, S., Lutfalla, G., Weissenbach, J. and Petit, C. (1992) Structure of the gene responsible for the X-linked Kallmann syndrome and of its homologous pseudogene on Y chromosome. Nature Genetics, 2, 305-310.

Lutfalla, G., Holland, S.J., Cinato, E., Monneron, D., Reboul, J., Rogers, N.C., Smith, J.M., Stark, G.R., Gardiner, K., Mogensen, K.E., Kerr, I.M. and Uz�, G. (1995).Mutant U5A cells are complemented by an interferon alpha/beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster.EMBO J. 14, 5100-5108.

Reboul, J., Gardiner, K., Monneron, D., Uz�, G. and Lutfalla, G. (1999) Comparative genomic analysis of the interferon/interleukin-10 receptor gene cluster. Genome Research, 9, 242-250.

Remoli ME, Giacomini E, Lutfalla G, Dondi E, Orefici G, Battistini A, Uze G, Pellegrini S, Coccia E (2002) Selective expression of type I IFN genes in human dendritic cells infected with Mycobacterium tuberculosis. J Immunol. 2002 Jul 1;169(1):366-74.

Weil, M., Lutfalla, G., Mogensen, E., Chandre, F., Berthomieu, A., Berticat, C., Pasteur, N., Philips, A., Fort, P. and Raymond, M. (2003) Comparative genomics: Insecticide resistance in mosquito vectors.Nature. 423:136-7