PUBLICATION
prdm1a drives a fate switch between hair cells of different mechanosensory organs
- Authors
- Sandler, J.E., Tsai, Y.Y., Chen, S., Sabin, L., Lush, M.E., Sur, A., Ellis, E., Tran, N.T.T., Cook, M., Scott, A.R., Kniss, J.S., Farrell, J.A., Piotrowski, T.
- ID
- ZDB-PUB-250819-1
- Date
- 2025
- Source
- Nature communications 16: 76627662 (Journal)
- Registered Authors
- Farrell, Jeffrey, Kniss, Jonathan, Lush, Mark E., Piotrowski, Tatjana
- Keywords
- none
- Datasets
- GEO:GSE268538
- MeSH Terms
-
- Mutation
- Positive Regulatory Domain I-Binding Factor 1*/genetics
- Positive Regulatory Domain I-Binding Factor 1*/metabolism
- Regeneration
- Hair Cells, Auditory*/cytology
- Hair Cells, Auditory*/metabolism
- Animals
- Zebrafish Proteins*/genetics
- Zebrafish Proteins*/metabolism
- Cell Differentiation/genetics
- Lateral Line System*/cytology
- Lateral Line System*/metabolism
- Zebrafish/genetics
- Gene Expression Regulation, Developmental
- Gene Regulatory Networks
- PubMed
- 40825768 Full text @ Nat. Commun.
Citation
Sandler, J.E., Tsai, Y.Y., Chen, S., Sabin, L., Lush, M.E., Sur, A., Ellis, E., Tran, N.T.T., Cook, M., Scott, A.R., Kniss, J.S., Farrell, J.A., Piotrowski, T. (2025) prdm1a drives a fate switch between hair cells of different mechanosensory organs. Nature communications. 16:76627662.
Abstract
Vertebrate inner ear mechanosensory hair cells detect sound and gravitational forces. Additionally, fishes have homologous lateral line hair cells in the skin that detect water vibrations for orientation and predator avoidance. Hair cells in the lateral line and ear of fishes and other non-mammalian vertebrates regenerate readily after damage, but mammalians lack this ability, causing deafness and vestibular defects. As yet, experimental attempts at hair cell regeneration in mice result in incompletely differentiated and immature hair cells. Despite differences in regeneration capabilities, the gene regulatory networks (GRNs) driving hair cell maturation during development are highly similar across vertebrates. Here, we show that the transcription factor prdm1a plays a key role in the hair cell fate GRN in the zebrafish lateral line. Mutating prdm1a respecifies lateral line hair cells into ear hair cells, altering morphology and transcriptome. Understanding how transcription factors control diverse hair cell fates in zebrafish is crucial for understanding the yet unsolved regeneration of diverse hair cells in mammalian ears to restore hearing and balance.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping