PUBLICATION
Somites are a source of nephron progenitors in zebrafish
- Authors
- Peng, Z., Vanichapol, T., Nguyen, P.D., Chang, H.G., Kocha, K.M., O'Brien, L.L., Currie, P.D., Huang, P., Davidson, A.J.
- ID
- ZDB-PUB-250728-18
- Date
- 2025
- Source
- Nature communications 16: 69146914 (Journal)
- Registered Authors
- Currie, Peter D., Davidson, Alan, Huang, Peng, Kocha, Katrinka
- Keywords
- none
- Datasets
- GEO:GSE286280
- MeSH Terms
-
- Animals
- Nephrons*/cytology
- Nephrons*/embryology
- Nephrons*/metabolism
- Animals, Genetically Modified
- Stem Cells*/cytology
- Kidney/embryology
- Mesoderm/cytology
- Gene Expression Regulation, Developmental
- Zebrafish*/embryology
- Somites*/cytology
- Somites*/embryology
- Somites*/metabolism
- Somites*/transplantation
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism
- PubMed
- 40715167 Full text @ Nat. Commun.
Citation
Peng, Z., Vanichapol, T., Nguyen, P.D., Chang, H.G., Kocha, K.M., O'Brien, L.L., Currie, P.D., Huang, P., Davidson, A.J. (2025) Somites are a source of nephron progenitors in zebrafish. Nature communications. 16:69146914.
Abstract
For over a century it has been believed that the vertebrate kidney arises exclusively from the intermediate mesoderm. Here, we overturn this paradigm by demonstrating that some nephrons, the functional units of the kidney, originate from the somites- blocks of paraxial mesoderm best known for their contribution to muscle and connective tissues. Using a combination of the GESTALT technique to assign developmental ancestry, somite transplantation experiments and Cre-lox fate-mapping, we show that somites can contribute to the nephrons in the adult zebrafish kidney. Our findings uncover an unexpected developmental connection between the somites and kidneys, potentially offering new pathways for developing regenerative treatments for kidney diseases.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping