PUBLICATION
Competing signaling pathways controls electrotaxis
- Authors
- Kulkarni, S., Tebar, F., Rentero, C., Zhao, M., S�ez, P.
- ID
- ZDB-PUB-250429-2
- Date
- 2025
- Source
- iScience 28: 112329112329 (Journal)
- Registered Authors
- Keywords
- Biophysics, Cell biology, Mechanobiology
- MeSH Terms
- none
- PubMed
- 40292314 Full text @ iScience
Citation
Kulkarni, S., Tebar, F., Rentero, C., Zhao, M., S�ez, P. (2025) Competing signaling pathways controls electrotaxis. iScience. 28:112329112329.
Abstract
Understanding how cells follow exogenous cues is a key question for biology, medicine, and bioengineering. Growing evidence shows that electric fields represent a precise and programmable method to control cell migration. Most data suggest that the polarization of membrane proteins and the following downstream signaling are central to electrotaxis. Unfortunately, how these multiple mechanisms coordinate with the motile machinery of the cell is still poorly understood. Here, we develop a mechanistic model that explains electrotaxis across different cell types. Using the zebrafish proteome, we identify membrane proteins directly related to migration signaling pathways that polarize anodally and cathodally. Further, we show that the simultaneous and asymmetric distribution of these membrane receptors establish multiple cooperative and competing stimuli for directing the anodal and cathodal migration of the cell. Using electric fields, we enhance, cancel, or switch directed cell migration, with clear implications in promoting tissue regeneration or arresting tumor progression.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping