PUBLICATION
Faberidilactone A, a Sesquiterpene Dimer, Inhibits Hepatocellular Carcinoma Progression Through Apoptosis, Ferroptosis, and Anti-Metastatic Mechanisms
- Authors
- Cao, R., Liu, Y., Bao, J., Rong, M., Xu, J., Liao, H., Guo, Y.
- ID
- ZDB-PUB-250313-35
- Date
- 2025
- Source
- Molecules 30: (Journal)
- Registered Authors
- Keywords
- FAK, STAT3, antitumor, faberidilactone A, sesquiterpenoid dimer, zebrafish
- MeSH Terms
-
- STAT3 Transcription Factor/metabolism
- Sesquiterpenes*/chemistry
- Sesquiterpenes*/pharmacology
- Humans
- Reactive Oxygen Species/metabolism
- Apoptosis*/drug effects
- Signal Transduction/drug effects
- Cell Line, Tumor
- Hep G2 Cells
- Carcinoma, Hepatocellular*/drug therapy
- Carcinoma, Hepatocellular*/metabolism
- Carcinoma, Hepatocellular*/pathology
- Liver Neoplasms*/drug therapy
- Liver Neoplasms*/metabolism
- Liver Neoplasms*/pathology
- Ferroptosis*/drug effects
- Neoplasm Metastasis
- Cell Movement/drug effects
- Zebrafish*
- Cell Proliferation*/drug effects
- Animals
- PubMed
- 40076318 Full text @ Molecules
Citation
Cao, R., Liu, Y., Bao, J., Rong, M., Xu, J., Liao, H., Guo, Y. (2025) Faberidilactone A, a Sesquiterpene Dimer, Inhibits Hepatocellular Carcinoma Progression Through Apoptosis, Ferroptosis, and Anti-Metastatic Mechanisms. Molecules. 30:.
Abstract
Cancer remains a significant global public health challenge, with hepatocellular carcinoma (HCC) ranking among the top five malignancies in terms of mortality. Faberidilactone A, a sesquiterpenoid dimer isolated from Inula japonica, exhibits potent cytotoxicity against various human tumor cell lines and demonstrates remarkable antitumor potential. In vitro studies using HepG2 cells revealed that faberidilactone A induces apoptosis and ferroptosis, causes cell cycle arrest, enhances the production of intracellular reactive oxygen species (ROS), and disrupts mitochondrial function. Mechanistic investigations via Western blot analysis indicated that faberidilactone A impedes HepG2 cell proliferation by modulating the signal transducer and activator of the transcription 3 (STAT3) signaling pathway and inhibits metastasis by affecting the focal adhesion kinase (FAK) pathway. In vivo experiments using a zebrafish model demonstrated that faberidilactone A effectively suppresses the dissemination and metastasis of HepG2 cells and exhibits anti-angiogenic properties. When the concentration of faberidilactone A reached 10 µM, the inhibition rates of tumor proliferation, migration, and intersegmental vessels (ISVs) length were 76.9%, 72.6%, and 46.2%, respectively. These findings underscore the therapeutic potential of faberidilactone A as a promising agent for HCC treatment.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping