PUBLICATION
Long-Term Yo-Yo Dieting Exaggerates Liver Steatosis and Lesions but Preserves Muscle Performance in Male Zebrafish
- Authors
- Hsu, T.C., Chiang, C.H., Liu, I.H., Wang, C.Y., Chen, C.Y.
- ID
- ZDB-PUB-241218-11
- Date
- 2024
- Source
- International Journal of Molecular Sciences 25(23): (Journal)
- Registered Authors
- Liu, I-Hsuan
- Keywords
- exercise, hepatosteatosis, high-calorie intake, muscle performance, weight cycling, zebrafish
- MeSH Terms
-
- Muscle, Skeletal/metabolism
- Muscle, Skeletal/pathology
- Animals
- Zebrafish*
- Adipose Tissue/metabolism
- Diet
- Energy Intake
- Male
- Lipid Metabolism
- Liver*/metabolism
- Liver*/pathology
- Fatty Liver*/etiology
- Fatty Liver*/metabolism
- Fatty Liver*/pathology
- PubMed
- 39684936 Full text @ Int. J. Mol. Sci.
Citation
Hsu, T.C., Chiang, C.H., Liu, I.H., Wang, C.Y., Chen, C.Y. (2024) Long-Term Yo-Yo Dieting Exaggerates Liver Steatosis and Lesions but Preserves Muscle Performance in Male Zebrafish. International Journal of Molecular Sciences. 25(23):.
Abstract
Weight regain within one year after weight loss is frequently observed and is referred to as yo-yo dieting or weight cycling. In this study, we explore the effects of yo-yo dieting on the liver, adipose tissue, and muscle characteristics of male zebrafish. Four-month-old AB wild-type male zebrafish were randomly assigned to three groups: high-calorie intake (H, seven meals per day), low-calorie intake (L, two meals per day), and yo-yo diet (the low- and high-calorie alternation switched every two weeks) groups. Feeding the fish the H diet for over 8 weeks led to steatosis and damage to the liver. The yo-yo diet reduced liver lipid accumulation at week eight but caused a similar degree of lipid accumulation as the H diet thereafter. It was found that twenty weeks of yo-yo dieting actually exacerbated hepatic damage. Compared to the L diet, feeding the fish on the yo-yo and H diets for a period of 20 weeks significantly increased the size of muscle fibers, resulting in higher speed during burst swimming and a significant increase in the size and number of adipocytes in the abdominal tissue. To summarize, short-term yo-yo dieting was found to attenuate hepatosteatosis and maintain fast-twitch muscle function. Long-term yo-yo dieting preserved fast-twitch muscle function and muscle fiber size; however, it exacerbated the pathological changes in the liver.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping