PUBLICATION
Rotenone exposure causes features of Parkinson`s disease pathology linked with muscle atrophy in developing zebrafish embryo
- Authors
- Ranasinghe, T., Seo, Y., Park, H.C., Choe, S.K., Cha, S.H.
- ID
- ZDB-PUB-241028-1
- Date
- 2024
- Source
- Journal of hazardous materials 480: 136215136215 (Journal)
- Registered Authors
- Cha, Seon-Heui, Choe, Seong-Kyu, Park, Hae-Chul
- Keywords
- Muscle atrophy, Parkinson's disease, Rotenone, Zebrafish
- MeSH Terms
-
- alpha-Synuclein/metabolism
- Behavior, Animal/drug effects
- Insecticides/toxicity
- Rotenone*/toxicity
- Animals
- Parkinson Disease/pathology
- Muscular Atrophy*/chemically induced
- Muscular Atrophy*/pathology
- Embryo, Nonmammalian*/drug effects
- Dopaminergic Neurons/drug effects
- Dopaminergic Neurons/pathology
- Disease Models, Animal
- Zebrafish*
- PubMed
- 39461288 Full text @ J. Hazard. Mater.
Citation
Ranasinghe, T., Seo, Y., Park, H.C., Choe, S.K., Cha, S.H. (2024) Rotenone exposure causes features of Parkinson`s disease pathology linked with muscle atrophy in developing zebrafish embryo. Journal of hazardous materials. 480:136215136215.
Abstract
Parkinson's disease (PD) is associated with both genetic and environmental factors; however, sporadic forms of PD account for > 90 % of cases, and PD prevalence has doubled in the past 25 years. Depending on the importance of the environmental factors, various neurotoxins are used to induce PD both in vivo and in vitro. Unlike other neurodegenerative diseases, PD can be induced in vivo using specific neurotoxic chemicals. However, no chemically induced PD model is available because of the sporadic nature of PD. Rotenone is a pesticide that accelerates the induction of PD and exhibits the highest toxicity in fish, unlike other pesticides. Therefore, in this study, we aimed to establish a model exhibiting PD pathologies such as dysfunction of DArgic neuron, aggregation of ɑ-synuclein, and behavioral abnormalities, which are known features of PD pathology, by rotenone exposure at an environmentally relevant concentration (30 nM) in developing zebrafish embryos. Our results provide direct evidence for the association between PD and muscle degeneration by confirming rotenone-induced muscle atrophy. Therefore, we conclude that the rotenone-induced model presents non-motor and motor defects with extensive studies related to muscle atrophy.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping