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Research
General Information
ZIRC
ZFIN ID: ZDB-PERS-020516-1
Park, Hae-Chul
Email: hcpark67@korea.ac.kr
URL:
Affiliation: Hae-Chul Park Lab
Address: Department of Medical Science, Korea university Ansan Hospital, 516 Gojan1-dong, Danwon-Gu, Ansan-Si, Gyeonggido, South Korea
Country: United States
Phone: +82-31-412-6725
Fax:
Orcid ID:


BIOGRAPHY AND RESEARCH INTERESTS


PUBLICATIONS
Kim, M., Jo, Y., Hong, J.H., Kim, S., Yoon, S., Song, K.D., Kang, S., Lee, B., Kim, G.H., Park, H.C., Choi, W. (2019) Label-free neuroimaging in vivo using synchronous angular scanning microscopy with single-scattering accumulation algorithm. Nature communications. 10:3152
Kim, S., Chung, A.Y., Na, J.E., Lee, S.J., Jeong, S.H., Kim, E., Sun, W., Rhyu, I.J., Park, H.C. (2019) Myelin degeneration induced by mutant superoxide dismutase 1 accumulation promotes amyotrophic lateral sclerosis. Glia. 67(10):1910-1921
Kim, E., Jeong, I., Chung, A.Y., Kim, S., Kwon, S.H., Seong, J.Y., Park, H.C. (2019) Distribution and neuronal circuit of spexin 1/2 neurons in the zebrafish CNS. Scientific Reports. 9:5025
Rim, C.H., Koun, S., Park, H.C., Lee, S., Kim, C.Y. (2019) Radioprotective effects of Mistletoe extract in Zebrafish embryos in vivo. International Journal of Radiation Biology. 95(8):1150-1159
Shim, J.S., Kim, B., Park, H.C., Ryu, J.J. (2018) Temporal Control of WNT Activity Regulates Tooth Number in Fish. Journal of dental research. 98(3):339-346
Rah, Y.C., Park, S., Koun, S., Park, H.C., Choi, J. (2018) In vivo assay of the ethanol-induced embryonic hair cell loss and the protective role of the retinoic and folic acid in zebrafish larvae (Danio rerio). Alcohol (Fayetteville, N.Y.). 75:113-121
Rah, Y.C., Han, E.J., Park, S., Rhee, J., Koun, S., Park, H.C., Choi, J. (2018) In vivo assay of the potential gadolinium-induced toxicity for sensory hair cells using a zebrafish animal model. Journal of applied toxicology : JAT. 38(11):1398-1404
Jeong, I., Kim, E., Kim, S., Kim, H.K., Lee, D.W., Seong, J.Y., Park, H.C. (2018) mRNA expression and metabolic regulation of npy and agrp1/2 in the zebrafish brain. Neuroscience letters. 668:73-79
Jo, M., Chung, A.Y., Yachie, N., Seo, M., Jeon, H., Nam, Y., Seo, Y., Kim, E., Zhong, Q., Vidal, M., Park, H.C., Roth, F., Suk, K. (2017) Yeast genetic interaction screen of human genes associated with amyotrophic lateral sclerosis: identification of MAP2K5 kinase as a potential drug target. Genome research. 27(9):1487-1500
Rah, Y.C., Yoo, M.H., Choi, J., Park, S., Park, H.C., Oh, K.H., Lee, S.H., Kwon, S.Y. (2017) In vivo assessment of hair cell damage and developmental toxicity caused by gestational caffeine exposure using zebrafish (Danio rerio) models. Neurotoxicology and teratology. 64:1-7
Jang, H.W., Chun, S.H., Park, H.C., Ryu, H.J., Kim, I.H. (2017) Comparative study of dual-pulsed 1,064 nm Q-switched Nd:YAG laser and single-pulsed 1,064 nm Q-switched Nd:YAG laser by using zebrafish model and prospective split-face analysis of facial melasma. Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology. 19(2):114-123
Ryu, H.J., Lee, J.M., Jang, H.W., Park, H.C., Rhyu, I.J., Kim, I.H. (2016) Morphologic Changes of Zebrafish Melanophore after Intense Pulsed Light and Q-Switched Nd:YAG Laser Irradiation. Annals of dermatology. 28:711-717
Kim, E., Jeong, I., Kim, S., Kim, H.K., Lee, D.W., Kim, B., Seong, J.Y., Bae, Y.K., Ryu, J.H., Park, H.C. (2016) Distribution of galanin receptor 2b neurons and interaction with galanin in the zebrafish central nervous system. Neuroscience letters. 628:153-60
Yoo, M.H., Rah, Y.C., Choi, J., Park, S., Park, H.C., Oh, K.H., Lee, S.H., Kwon, S.Y. (2016) Embryotoxicity and hair cell toxicity of silver nanoparticles in zebrafish embryos. International journal of pediatric otorhinolaryngology. 83:168-74
Chang, J., Choi, J., Rah, Y.C., Yoo, M.H., Oh, K.H., Im, G.J., Lee, S.H., Kwon, S.Y., Park, H.C., Chae, S.W., Jung, H.H. (2016) Sodium Selenite Acts as an Otoprotectant against Neomycin-Induced Hair Cell Damage in a Zebrafish Model. PLoS One. 11:e0151557
Rah, Y.C., Choi, J., Yoo, M.H., Yum, G., Park, S., Oh, K.H., Lee, S.H., Kwon, S.Y., Cho, S.H., Kim, S., Park, H.C. (2015) Ecabet sodium alleviates neomycin-induced hair cell damage. Free radical biology & medicine. 89:1176-83
Kim, S., Lee, Y.I., Chang, K.Y., Lee, D.W., Cho, S.C., Ha, Y.W., Na, J.E., Rhyu, I.J., Park, S.C., Park, H.C. (2015) Promotion of Remyelination by Sulfasalazine in a Transgenic Zebrafish Model of Demyelination. Molecules and cells. 38(11):1013-21
Yoo, M.G., So, B.J., Lee, J.M., Kim, D.H., Park, H.C., Ryu, H.J., Kim, I.H. (2015) Influence of Pulse Type on Subcellular Selective Photothermolysis of Melanosomes in Adult Zebrafish Skin Following 1,064-nm, Q-switched, Nd:YAG Laser Irradiation: A Pilot Study. Annals of dermatology. 27:230-232
Paik, H., Chung, A.Y., Park, H.C., Park, R.W., Suk, K., Kim, J., Kim, H., Lee, K., Butte, A.J. (2015) Repurpose terbutaline sulfate for amyotrophic lateral sclerosis using electronic medical records. Scientific Reports. 5:8580
Choi, J., Chang, J., Jun, H.J., Im, G.J., Chae, S.W., Lee, S.H., Kwon, S.Y., Jung, H.H., Chung, A.Y., Park, H.C. (2014) Protective role of edaravone against neomycin-induced ototoxicity in zebrafish. Journal of applied toxicology : JAT. 34:554-61
Song, J.J., Chang, J., Choi, J., Im, G.J., Chae, S.W., Lee, S.H., Kwon, S.Y., Jung, H.H., Chung, A.Y., Park, H.C., and Choi, J. (2014) Protective role of NecroX-5 against neomycin-induced hair cell damage in zebrafish. Archives of toxicology. 88(2):435-41
Kim, H.Y., Yang, D.H., Shin, S.W., Kim, M.Y., Yoon, J.H., Kim, S., Park, H.C., Kang, D.W., Min, D., Hur, M.W., and Choi, K.Y. (2014) CXXC5 is a transcriptional activator of Flk-1 and mediates bone morphogenic protein-induced endothelial cell differentiation and vessel formation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 28(2):615-26
Chang, J., Im, G.J., Chae, S.W., Lee, S.H., Kwon, S.Y., Jung, H.H., Chung, A.Y., Park, H.C., and Choi, J. (2013) Protective Role of Trimetazidine Against Neomycin-induced Hair Cell Damage in Zebrafish. Clinical and experimental otorhinolaryngology. 6(4):219-225
Chung, A.Y., Kim, P.S., Kim, S., Kim, E., Kim, D., Jeong, I., Kim, H.K., Ryu, J.H., Kim, C.H., Choi, J., Seo, J.H., and Park, H.C. (2013) Generation of demyelination models by targeted ablation of oligodendrocytes in the zebrafish CNS. Molecules and cells. 36(1):82-7
Kim, K.H., Park, H.J., Kim, J.H., Kim, S., Williams, D.R., Kim, M.K., Jung, Y.D., Teraoka, H., Park, H.C., Choy, H.E., Shin, B.A., and Choi, S.Y. (2013) Cyp1a reporter zebrafish reveals target tissues for dioxin. Aquatic toxicology (Amsterdam, Netherlands). 134-135C:57-65
Hong, S.J., Im, G.J., Chang, J., Chae, S.W., Lee, S.H., Kwon, S.Y., Jung, H.H., Chung, A.Y., Park, H.C., and Choi, J. (2013) Protective effects of edaravone against cisplatin-induced hair cell damage in zebrafish. International journal of pediatric otorhinolaryngology. 77(6):1025-1031
Choi, J., Im, G.J., Chang, J., Chae, S.W., Lee, S.H., Kwon, S.Y., Chung, A.Y., Park, H.C., and Jung, H.H. (2013) Protective effects of apocynin on cisplatin-induced ototoxicity in an auditory cell line and in zebrafish. Journal of applied toxicology : JAT. 33(2):125-133
Chung, A.Y., Kim, S., Kim, E., Kim, D., Jeong, I., Cha, Y.R., Bae, Y.K., Park, S.W., Lee, J., and Park, H.C. (2013) Indian hedgehog B function is required for the specification of oligodendrocyte progenitor cells in the zebrafish CNS. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(4):1728-1733
Kim, J.H., Kim, D.H., Kim, J.H., Lee, S.G., Kim, H.S., Park, H.C., and Kim, I.H. (2012) Recovery of Pigmentation Following Selective Photothermolysis in Adult Zebrafish Skin: Clinical Implications for Laser Toning Treatment of Melasma. Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology. 14(6):277-285
Kim, S., Kim, J.D., Chung, A.Y., Kim, H.S., Kim, Y.S., Kim, M.J., Koun, S., Lee, Y.M., Rhee, M., Park, H.C., and Huh, T.L. (2012) Antagonistic Regulation of PAF1C and p-TEFb Is Required for Oligodendrocyte Differentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(24):8201-8207
Revathy, K.S., Umasuthan, N., Whang, I., Lee, Y., Lee, S., Oh, M.J., Jung, S.J., Choi, C.Y., Park, C.J., Park, H.C., and Lee, J. (2012) A novel acute phase reactant, serum amyloid A-like 1, from Oplegnathus fasciatus: Genomic and molecular characterization and transcriptional expression analysis. Developmental and comparative immunology. 37(2):294-305
Kim, H., Lee, S., Park, H.C., Lee, W.H., Lee, M.S., and Suk, K. (2011) Modulation of glial and neuronal migration by lipocalin-2 in zebrafish. Immune Network. 11(6):342-347
Kim, S., Chung, A.Y., Kim, D., Kim, Y.S., Kim, H.S., Kwon, H.W., Huh, T.L., Park, H.C. (2011) Tcf3 function is required for the inhibition of oligodendroglial fate specification in the spinal cord of zebrafish embryos. Molecules and cells. 32(4):383-8
Chung, A.Y., Kim, S., Kim, H., Bae, Y.K., and Park, H.C. (2011) Microarray Screening for Genes Involved in Oligodendrocyte Differentiation in the Zebrafish CNS. Experimental Neurobiology. 20(2):85-91
Kim, J.H., Kim, H., Park, H.C., and Kim, I.H. (2010) Subcellular Selective Photothermolysis of Melanosomes in Adult Zebrafish Skin Following 1064-nm Q-Switched Nd:YAG Laser Irradiation. The Journal of investigative dermatology. 130(9):2333-2335
Chung, A.Y., Kim, M.J., Kim, D., Bang, S., Hwang, S.W., Lim, C.S., Lee, S., Park, H.C., and Huh, T.L. (2010) Neuron-specific expression of atp6v0c2 in zebrafish CNS. Developmental dynamics : an official publication of the American Association of Anatomists. 239(9):2501-2508
Son, S.W., Kim, J.H., Kim, S.H., Kim, H., Chung, A.Y., Choo, J.B., Oh, C.H., and Park, H.C. (2009) Intravital imaging in zebrafish using quantum dots. Skin research and technology. 15(2):157-160
Lee, S., Park, J.Y., Lee, W.H., Kim, H., Park, H.C., Mori, K., and Suk, K. (2009) Lipocalin-2 is an autocrine mediator of reactive astrocytosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(1):234-249
Kim, H., Kim, S., Chung, A.Y., Bae, Y.K., Hibi, M., Lim, C.S., and Park, H.C. (2008) Notch-regulated perineurium development from zebrafish spinal cord. Neuroscience letters. 448(3):240-244
Kim, H.T., Kim, E.H., Yoo, K.W., Lee, M.S., Choi, J.H., Park, H.C., Yeo, S.Y., Lee, D.S., and Kim, C.H. (2008) Isolation and expression analysis of Alzheimer's disease-related gene xb51 in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 237(12):3921-3926
Kim, S., Kim, S.H., Kim, H., Chung, A.Y., Cha, Y.I., Kim, C.H., Huh, T.L., and Park, H.C. (2008) Frizzled 8a function is required for oligodendrocyte development in the zebrafish spinal cord. Developmental dynamics : an official publication of the American Association of Anatomists. 237(11):3324-3331
Kim, H., Shin, J., Kim, S., Poling, J., Park, H.C., and Appel, B. (2008) Notch-regulated oligodendrocyte specification from radial glia in the spinal cord of zebrafish embryos. Developmental dynamics : an official publication of the American Association of Anatomists. 237(8):2081-2089
Kucenas, S., Takada, N., Park, H.C., Woodruff, E., Broadie, K., and Appel, B. (2008) CNS-derived glia ensheath peripheral nerves and mediate motor root development. Nature Neuroscience. 11(2):143-151
Park, H.C., Shin, J., Roberts, R.K., and Appel, B. (2007) An olig2 reporter gene marks oligodendrocyte precursors in the postembryonic spinal cord of zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 236(12):3402-3407
Shin, J., Poling, J., Park, H.C., and Appel, B. (2007) Notch signaling regulates neural precursor allocation and binary neuronal fate decisions in zebrafish. Development (Cambridge, England). 134(10):1911-1920
Won, M., Ro, H., Park, H.C., Kim, K.E., Huh, T.L., Kim, C.H., and Rhee, M. (2006) Dynamic expression patterns of zebrafish 1G5 (1G5z), a calmodulin kinase-like gene in the developing nervous system. Developmental dynamics : an official publication of the American Association of Anatomists. 235(3):835-842
Park, H.C., Boyce, J., Shin, J., and Appel, B. (2005) Oligodendrocyte specification in zebrafish requires notch-regulated cyclin-dependent kinase inhibitor function. The Journal of neuroscience : the official journal of the Society for Neuroscience. 25(29):6836-6844
Park, H.C., Shin, J., and Appel, B. (2004) Spatial and temporal regulation of ventral spinal cord precursor specification by Hedgehog signaling. Development (Cambridge, England). 131(23):5959-5969
Park, H.-C. and Appel, B. (2003) Delta-Notch signaling regulates oligodendrocyte specification. Development (Cambridge, England). 130(16):3747-3755
Yoo, K.W., Kim, C.H., Park, H.C., Kim, S.H., Kim, H.S., Hong, S.K., Han, S., Rhee, M., and Huh, T.L. (2003) Characterization and expression of a presomitic mesoderm-specific mespo gene in zebrafish. Development genes and evolution. 213(4):203-206
Shin, J., Park, H.-C., Topczewska, J.M., Mawdsley, D.J., and Appel, B. (2003) Neural cell fate analysis in zebrafish using olig2 BAC transgenics. Methods in cell science : an official journal of the Society for In Vitro Biology. 25(1-2):7-14
Kim, S.-H., Shin, J., Park, H.-C., Yeo, S.-Y., Hong, S.-K., Han, S., Rhee, M., Kim, C.-H., Chitnis, A.B., and Huh, T.-L. (2002) Specification of an anterior neuroectoderm patterning by Frizzled8a-mediated Wnt8b signalling during late gastrulation in zebrafish. Development (Cambridge, England). 129(19):4443-4455
Park, H.-C., Mehta, A., Richardson, J.S., and Appel, B. (2002) olig2 is required for zebrafish primary motor neuron and oligodendrocyte development. Developmental Biology. 248(2):356-368
Park, H.-C., Hong, S.-K., Kim, H.-S., Kim, S.-H., Yoon, E.-J., Kim, C.-H., Miki, N., and Huh, T.-L. (2000) Structural comparison of zebrafish Elav/Hu and their differential expressions during neurogenesis. Neuroscience letters. 279(2):81-84
Kim, S.-H., Park, H.-C., Yeo, S.-Y., Hong, S.-K., Choi, J.W., Kim, C.-H., Weinstein, B.M., and Huh, T.-L. (1998) Characterization of two frizzled8 homologues expressed in the embryonic shield and prechordal plate of zebrafish embryos. Mechanisms of Development. 78:193-201

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